DegronMD

Uniprot ID: P40337

Source protein: von Hippel-Lindau disease tumor suppressor

Source gene: VHL

Class: DEG_APCC_DBOX_1

Location: 59:67

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9698

ASA_SCORE: 73.5889

COIL: 0.6701

CONS_SCORE: 0.4694

DSS_SCORE: 0.5518

HELIX: 0.0366

FCONS_SCORE: 1.1914

RIG_SCORE: 0.6904

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E52K	TCGA-AZ-6599	COAD	TCGA	PRPVLRSVN	DEG_APCC_DBOX_1	0.1389
p.E52K	DO10606	COAD	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	0.1389
p.S65W	TCGA-B0-5077	KIRC	TCGA	PRPVLRSVN	DEG_APCC_DBOX_1	0.6763
p.S65W	DO18412	KIRC	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	0.6763
p.S65W	ACH-000272	Kidney Cancer	CCLE	PRPVLRSVN	DEG_APCC_DBOX_1	0.6763
p.V74D	TCGA-B0-5097	KIRC	TCGA	PRPVLRSVN	DEG_APCC_DBOX_1	0.1389
p.V74D	TCGA-BP-5175	KIRC	TCGA	PRPVLRSVN	DEG_APCC_DBOX_1	0.1389
p.V74D	DO19370	KIRC	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	0.1389
p.V74D	DO16153	KIRC	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	0.1389
p.V74D	DO233481	RECA	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	0.1389
p.P71R	DO233900	GACA	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	0.2222
p.V74G	DO17085	KIRC	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	0.1389
p.V62M	DO18839	KIRC	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	0.6097
p.S65L	DO47156	RECA	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	0.6556
p.S65L	DO233374	RECA	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	0.6556
p.S65P	DO232116	RECA	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	0.5641
p.V74A	DO229253	THCA	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	0.1389
p.E70D	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PRPVLRSVN	DEG_APCC_DBOX_1	0.25
p.E70D	ACH-000964	Leukemia	CCLE	PRPVLRSVN	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40337	von Hippel-Lindau disease tumor suppressor	DEG_APCC_DBOX_1	59:67	PRPVLRSVN	APC,CDC20,FZR1	0.9698	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons