DegronMD

Uniprot ID: Q96IW2

Source protein: SH2 domain-containing adapter protein D

Source gene: SHD

Class: DEG_SCF_FBW7_2

Location: 143:150

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 59.675

COIL: 0.7113

CONS_SCORE: 0.4795

DSS_SCORE: 0.7723

HELIX: 0.055

FCONS_SCORE: 1.1186

RIG_SCORE: 0.7042

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M133I	TCGA-AO-A03M	BRCA	TCGA	LYDTPYEE	DEG_SCF_FBW7_2	0.0556
p.M133I	TCGA-GV-A6ZA	BLCA	TCGA	LYDTPYEE	DEG_SCF_FBW7_2	0.0556
p.M133I	DO49776	BLCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.0556
p.M133I	DO2216	BRCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.0556
p.D157G	TCGA-CA-6715	COAD	TCGA	LYDTPYEE	DEG_SCF_FBW7_2	0.1389
p.D157G	DO9690	COAD	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.1389
p.G140E	TCGA-FW-A3R5	SKCM	TCGA	LYDTPYEE	DEG_SCF_FBW7_2	0.25
p.G140E	DO37406	SKCM	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.25
p.G140W	TCGA-IB-7651	PAAD	TCGA	LYDTPYEE	DEG_SCF_FBW7_2	0.25
p.G140W	DO233693	GACA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.25
p.G140W	DO46657	PAAD	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.25
p.Y144C	DO871	BOCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.7087
p.G138S	DO228483	BRCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.1944
p.G138S	DO230334	COCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.1944
p.G138S	DO229010	COCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.1944
p.G138S	DO229005	COCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.1944
p.G138S	DO48320	ESCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.1944
p.G138S	DO229505	LAML	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.1944
p.G138S	DO229022	LICA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.1944
p.G138S	DO230556	LUSC	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.1944
p.G138S	DO231102	LUSC	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.1944
p.V141M	DO233888	GACA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.2778
p.V141M	SIDM00095	Glioblastoma	GDSC	LYDTPYEE	DEG_SCF_FBW7_2	0.2778
p.V141M	SIDM01107	Melanoma	GDSC	LYDTPYEE	DEG_SCF_FBW7_2	0.2778
p.V141M	SNB75	central_nervous_system	COSMIC	LYDTPYEE	DEG_SCF_FBW7_2	0.2778
p.D152H	DO16136	KIRC	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96IW2	SH2 domain-containing adapter protein D	DEG_SCF_FBW7_2	143:150	LYDTPYEE	FBXW7	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons