DegronMD - Q96IW2(SHD)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P18A	TCGA-85-A4CL	LUSC	TCGA	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.2778
p.P18A	DO45454	LUSC	ICGC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.2778
p.M133I	TCGA-AO-A03M	BRCA	TCGA	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.0556
p.M133I	TCGA-GV-A6ZA	BLCA	TCGA	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.0556
p.M133I	DO49776	BLCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.0556
p.M133I	DO2216	BRCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.0556
p.P21H	TCGA-BH-A0HA	BRCA	TCGA	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation altering degron motif	0.6583
p.P21H	DO1658	BRCA	ICGC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation altering degron motif	0.6583
p.D157G	TCGA-CA-6715	COAD	TCGA	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.1389
p.D157G	DO9690	COAD	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.1389
p.G13S	TCGA-EE-A2GC	SKCM	TCGA	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.1389
p.G13S	DO37839	SKCM	ICGC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.1389
p.R32S	TCGA-EE-A2MD	SKCM	TCGA	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.1667
p.R32S	DO37851	SKCM	ICGC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.1667
p.G140E	TCGA-FW-A3R5	SKCM	TCGA	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.25
p.G140E	DO37406	SKCM	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.25
p.G140W	TCGA-IB-7651	PAAD	TCGA	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.25
p.G140W	DO233693	GACA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.25
p.G140W	DO46657	PAAD	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.25
p.Y144C	DO871	BOCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation altering degron motif	0.7087
p.G138S	DO228483	BRCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.1944
p.G138S	DO230334	COCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.1944
p.G138S	DO229010	COCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.1944
p.G138S	DO229005	COCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.1944
p.G138S	DO48320	ESCA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.1944
p.G138S	DO229505	LAML	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.1944
p.G138S	DO229022	LICA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.1944
p.G138S	DO230556	LUSC	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.1944
p.G138S	DO231102	LUSC	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.1944
p.G13V	DO50326	ESAD	ICGC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.1389
p.D24N	DO234230	ESAD	ICGC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation altering degron motif	0.5821
p.E27K	DO223116	ESCA	ICGC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.3056
p.V141M	DO233888	GACA	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.2778
p.V141M	SIDM00095	Glioblastoma	GDSC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.2778
p.V141M	SIDM01107	Melanoma	GDSC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.2778
p.V141M	SNB75	central nervous system	COSMIC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.2778
p.D152H	DO16136	KIRC	ICGC	LYDTPYEE	DEG_SCF_FBW7_2	143:150	Mutation rewiring degron network	0.2778
p.D29N	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.25
p.D29N	ACH-002263	Esophageal Cancer	CCLE	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.25
p.D29N	KYSE-220	oesophagus	COSMIC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.25
p.Y34N	SIDM00282	Colorectal Carcinoma	GDSC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.1111
p.Y34N	ACH-000998	Colon/Colorectal Cancer	CCLE	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.1111
p.Y34N	CW-2	large intestine	COSMIC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.1111
p.S28N	SIDM00333	Endometrial Carcinoma	GDSC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.2778
p.S28N	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.2778
p.S28N	MFE-319	endometrium	COSMIC	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.2778
p.R14Q	ACH-000937	Leukemia	CCLE	PPTPDYT	DEG_SCF_FBW7_1	20:26	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHD

UniProt ID: Q96IW2

Entrez ID: 56961

Protein name: SH2 domain-containing adapter protein D

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHD in