DegronMD

Uniprot ID: Q96IW2

Source protein: SH2 domain-containing adapter protein D

Source gene: SHD

Class: DEG_SCF_FBW7_1

Location: 20:26

E3 ligase: FBXW7

DEGRON score: 0.7945

ASA_SCORE: 89

COIL: 0.9323

CONS_SCORE: 0.4868

DSS_SCORE: 0.7325

HELIX: 0.054

FCONS_SCORE: 1.0213

RIG_SCORE: 0.637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P18A	TCGA-85-A4CL	LUSC	TCGA	PPTPDYT	DEG_SCF_FBW7_1	0.2778
p.P18A	DO45454	LUSC	ICGC	PPTPDYT	DEG_SCF_FBW7_1	0.2778
p.P21H	TCGA-BH-A0HA	BRCA	TCGA	PPTPDYT	DEG_SCF_FBW7_1	0.6583
p.P21H	DO1658	BRCA	ICGC	PPTPDYT	DEG_SCF_FBW7_1	0.6583
p.G13S	TCGA-EE-A2GC	SKCM	TCGA	PPTPDYT	DEG_SCF_FBW7_1	0.1389
p.G13S	DO37839	SKCM	ICGC	PPTPDYT	DEG_SCF_FBW7_1	0.1389
p.R32S	TCGA-EE-A2MD	SKCM	TCGA	PPTPDYT	DEG_SCF_FBW7_1	0.1667
p.R32S	DO37851	SKCM	ICGC	PPTPDYT	DEG_SCF_FBW7_1	0.1667
p.G13V	DO50326	ESAD	ICGC	PPTPDYT	DEG_SCF_FBW7_1	0.1389
p.D24N	DO234230	ESAD	ICGC	PPTPDYT	DEG_SCF_FBW7_1	0.5821
p.E27K	DO223116	ESCA	ICGC	PPTPDYT	DEG_SCF_FBW7_1	0.3056
p.D29N	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PPTPDYT	DEG_SCF_FBW7_1	0.25
p.D29N	ACH-002263	Esophageal Cancer	CCLE	PPTPDYT	DEG_SCF_FBW7_1	0.25
p.D29N	KYSE-220	oesophagus	COSMIC	PPTPDYT	DEG_SCF_FBW7_1	0.25
p.Y34N	SIDM00282	Colorectal Carcinoma	GDSC	PPTPDYT	DEG_SCF_FBW7_1	0.1111
p.Y34N	ACH-000998	Colon/Colorectal Cancer	CCLE	PPTPDYT	DEG_SCF_FBW7_1	0.1111
p.Y34N	CW-2	large_intestine	COSMIC	PPTPDYT	DEG_SCF_FBW7_1	0.1111
p.S28N	SIDM00333	Endometrial Carcinoma	GDSC	PPTPDYT	DEG_SCF_FBW7_1	0.2778
p.S28N	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPTPDYT	DEG_SCF_FBW7_1	0.2778
p.S28N	MFE-319	endometrium	COSMIC	PPTPDYT	DEG_SCF_FBW7_1	0.2778
p.R14Q	ACH-000937	Leukemia	CCLE	PPTPDYT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96IW2	SH2 domain-containing adapter protein D	DEG_SCF_FBW7_1	20:26	PPTPDYT	FBXW7	0.7945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons