DegronMD

Uniprot ID: P14550

Source protein: Aldo-keto reductase family 1 member A1

Source gene: AKR1A1

Class: LIG_APCC_ABBA_1

Location: 318:323

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.708

ASA_SCORE: 58.6833

COIL: 0.9092

CONS_SCORE: 0.2184

DSS_SCORE: 0.6439

HELIX: 0.0543

FCONS_SCORE: 1.0921

RIG_SCORE: 0.7494

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N322S	TCGA-29-1766	OV	TCGA	LYPFND	LIG_APCC_ABBA_1	0.5958
p.N322S	DO29288	OV	ICGC	LYPFND	LIG_APCC_ABBA_1	0.5958
p.P317L	TCGA-AP-A051	UCEC	TCGA	LYPFND	LIG_APCC_ABBA_1	0.3056
p.P317L	DO42673	UCEC	ICGC	LYPFND	LIG_APCC_ABBA_1	0.3056
p.R312M	TCGA-D3-A2J6	SKCM	TCGA	LYPFND	LIG_APCC_ABBA_1	0.1667
p.R312M	TCGA-EE-A181	SKCM	TCGA	LYPFND	LIG_APCC_ABBA_1	0.1667
p.R312M	DO37444	SKCM	ICGC	LYPFND	LIG_APCC_ABBA_1	0.1667
p.R312M	DO37901	SKCM	ICGC	LYPFND	LIG_APCC_ABBA_1	0.1667
p.L318M	TCGA-EE-A2GO	SKCM	TCGA	LYPFND	LIG_APCC_ABBA_1	0.5999
p.L318M	DO37823	SKCM	ICGC	LYPFND	LIG_APCC_ABBA_1	0.5999
p.A314S	TCGA-LN-A4A2	ESCA	TCGA	LYPFND	LIG_APCC_ABBA_1	0.2222
p.Y319N	DO224768	BRCA	ICGC	LYPFND	LIG_APCC_ABBA_1	0.5948
p.A314T	DO222503	COCA	ICGC	LYPFND	LIG_APCC_ABBA_1	0.2222
p.Y325C	DO232224	PBCA	ICGC	LYPFND	LIG_APCC_ABBA_1	0.7222
p.P317S	SIDM00973	Melanoma	GDSC	LYPFND	LIG_APCC_ABBA_1	0.3056
p.P317S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	LYPFND	LIG_APCC_ABBA_1	0.3056
p.P317S	SIDM00129	Melanoma	GDSC	LYPFND	LIG_APCC_ABBA_1	0.3056
p.P317S	SIDM00621	Ewing's Sarcoma	GDSC	LYPFND	LIG_APCC_ABBA_1	0.3056
p.P317S	SIDM01084	Osteosarcoma	GDSC	LYPFND	LIG_APCC_ABBA_1	0.3056
p.N322T	SIDM00118	Colorectal Carcinoma	GDSC	LYPFND	LIG_APCC_ABBA_1	0.5944
p.N322T	ACH-001081	Colon/Colorectal Cancer	CCLE	LYPFND	LIG_APCC_ABBA_1	0.5944
p.N322T	HCC2998	large_intestine	COSMIC	LYPFND	LIG_APCC_ABBA_1	0.5944
p.P324L	SIDM01409	Bladder Carcinoma	GDSC	LYPFND	LIG_APCC_ABBA_1	0.3056
p.P324R	ACH-000170	Non-Cancerous	CCLE	LYPFND	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14550	Aldo-keto reductase family 1 member A1	LIG_APCC_ABBA_1	318:323	LYPFND	APC,CDC20,FZR1	0.708	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons