DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 9448:9455

E3 ligase: FBXW7

DEGRON score: 0.6379

ASA_SCORE: 88.7375

COIL: 0.92

CONS_SCORE: 0

DSS_SCORE: 0.5134

HELIX: 0.0149

FCONS_SCORE: 0

RIG_SCORE: 0.5281

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S9458Y	TCGA-05-4410	LUAD	TCGA	LYSTPSGS	DEG_SCF_FBW7_1	0.25
p.S9458Y	DO25426	LUAD	ICGC	LYSTPSGS	DEG_SCF_FBW7_1	0.25
p.P9445S	TCGA-55-7994	LUAD	TCGA	LYSTPSGS	DEG_SCF_FBW7_1	0.25
p.P9445S	DO45311	LUAD	ICGC	LYSTPSGS	DEG_SCF_FBW7_1	0.25
p.S9453F	TCGA-77-6842	LUSC	TCGA	LYSTPSGS	DEG_SCF_FBW7_1	0.6871
p.S9453F	DO27413	LUSC	ICGC	LYSTPSGS	DEG_SCF_FBW7_1	0.6871
p.H9457R	TCGA-CV-5978	HNSC	TCGA	LYSTPSGS	DEG_SCF_FBW7_1	0.2778
p.H9457R	DO16023	HNSC	ICGC	LYSTPSGS	DEG_SCF_FBW7_1	0.2778
p.S9459F	TCGA-EY-A1GI	UCEC	TCGA	LYSTPSGS	DEG_SCF_FBW7_1	0.2222
p.S9459F	DO41211	UCEC	ICGC	LYSTPSGS	DEG_SCF_FBW7_1	0.2222
p.P9460S	TCGA-FR-A726	SKCM	TCGA	LYSTPSGS	DEG_SCF_FBW7_1	0.1944
p.P9460S	DO48665	SKCM	ICGC	LYSTPSGS	DEG_SCF_FBW7_1	0.1944
p.S9465Y	DO222798	COCA	ICGC	LYSTPSGS	DEG_SCF_FBW7_1	0.0556
p.S9444T	DO234270	ESAD	ICGC	LYSTPSGS	DEG_SCF_FBW7_1	0.2222
p.G9454V	DO234414	ESAD	ICGC	LYSTPSGS	DEG_SCF_FBW7_1	0.6421
p.P9445T	DO233783	GACA	ICGC	LYSTPSGS	DEG_SCF_FBW7_1	0.25
p.P9452Q	DO229028	LICA	ICGC	LYSTPSGS	DEG_SCF_FBW7_1	0.7035
p.S9453Y	DO228398	PRAD	ICGC	LYSTPSGS	DEG_SCF_FBW7_1	0.6009

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	9448:9455	LYSTPSGS	FBXW7	0.6379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons