DegronMD

Uniprot ID: A6NFN3

Source protein: RNA binding protein fox-1 homolog 3

Source gene: RBFOX3

Class: DEG_SCF_FBW7_1

Location: 47:53

E3 ligase: FBXW7

DEGRON score: 0.9831

ASA_SCORE: 78

COIL: 0.7829

CONS_SCORE: 0.3868

DSS_SCORE: 0.8155

HELIX: 0.0211

FCONS_SCORE: 1.0109

RIG_SCORE: 0.6594

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T49I	TCGA-BH-A18G	BRCA	TCGA	LYTPAQT	DEG_SCF_FBW7_1	0.7078
p.T49I	DO3686	BRCA	ICGC	LYTPAQT	DEG_SCF_FBW7_1	0.7078
p.P50T	DO229037	LICA	ICGC	LYTPAQT	DEG_SCF_FBW7_1	0.7031
p.Q52H	TCGA-GM-A2DO	BRCA	TCGA	LYTPAQT	DEG_SCF_FBW7_1	0.647
p.Q52H	DO2037	BRCA	ICGC	LYTPAQT	DEG_SCF_FBW7_1	0.647
p.H54Q	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	LYTPAQT	DEG_SCF_FBW7_1	0.3056
p.E56K	SIDM00935	Other Solid Cancers	GDSC	LYTPAQT	DEG_SCF_FBW7_1	0.25
p.P58T	DO228974	LICA	ICGC	LYTPAQT	DEG_SCF_FBW7_1	0.1944
p.E61V	TCGA-OR-A5KB	ACC	TCGA	LYTPAQT	DEG_SCF_FBW7_1	0.1111
p.E61K	DO228310	BRCA	ICGC	LYTPAQT	DEG_SCF_FBW7_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NFN3	RNA binding protein fox-1 homolog 3	DEG_SCF_FBW7_1	47:53	LYTPAQT	FBXW7	0.9831	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons