DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LYTPAQT
Uniprot ID:
A6NFN3
Source protein:
RNA binding protein fox-1 homolog 3
Source gene:
RBFOX3
Class:
DEG_SCF_FBW7_1
Location:
47:53
E3 ligase:
FBXW7
DEGRON score:
0.9831
ASA_SCORE:
78
COIL:
0.7829
CONS_SCORE:
0.3868
DSS_SCORE:
0.8155
HELIX:
0.0211
FCONS_SCORE:
1.0109
RIG_SCORE:
0.6594
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T49I
TCGA-BH-A18G
BRCA
TCGA
LYTPAQT
DEG_SCF_FBW7_1
0.7078
p.T49I
DO3686
BRCA
ICGC
LYTPAQT
DEG_SCF_FBW7_1
0.7078
p.Q52H
TCGA-GM-A2DO
BRCA
TCGA
LYTPAQT
DEG_SCF_FBW7_1
0.647
p.Q52H
DO2037
BRCA
ICGC
LYTPAQT
DEG_SCF_FBW7_1
0.647
p.E61V
TCGA-OR-A5KB
ACC
TCGA
LYTPAQT
DEG_SCF_FBW7_1
0.1111
p.E61K
DO228310
BRCA
ICGC
LYTPAQT
DEG_SCF_FBW7_1
0.1111
p.P58T
DO228974
LICA
ICGC
LYTPAQT
DEG_SCF_FBW7_1
0.1944
p.P50T
DO229037
LICA
ICGC
LYTPAQT
DEG_SCF_FBW7_1
0.7031
p.E56K
SIDM00935
Other Solid Cancers
GDSC
LYTPAQT
DEG_SCF_FBW7_1
0.25
p.H54Q
SIDM00939
Non-Small Cell Lung Carcinoma
GDSC
LYTPAQT
DEG_SCF_FBW7_1
0.3056
Drug responses associated with RBFOX3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LYTPAQT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NFN3
RNA binding protein fox-1 homolog 3
DEG_SCF_FBW7_1
47:53
LYTPAQT
FBXW7
0.9831
More...