DegronMD

Uniprot ID: O43464

Source protein: Serine protease HTRA2, mitochondrial

Source gene: HTRA2

Class: DEG_SCF_FBW7_1

Location: 450:457

E3 ligase: FBXW7

DEGRON score: 0.592

ASA_SCORE: 73.3375

COIL: 0.4478

CONS_SCORE: 0.3952

DSS_SCORE: 0.635

HELIX: 0.009

FCONS_SCORE: 0.8957

RIG_SCORE: 0.8296

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R445Q	TCGA-BR-6802	STAD	TCGA	LYVTPEVT	DEG_SCF_FBW7_1	0.1944
p.R442W	ACH-000982	Colon/Colorectal Cancer	CCLE	LYVTPEVT	DEG_SCF_FBW7_1	0.1111
p.R442W	ACH-001345	Colon/Colorectal Cancer	CCLE	LYVTPEVT	DEG_SCF_FBW7_1	0.1111
p.R442W	GP5d	large_intestine	COSMIC	LYVTPEVT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43464	Serine protease HTRA2, mitochondrial	DEG_SCF_FBW7_1	450:457	LYVTPEVT	FBXW7	0.592	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons