DegronMD - O43464(HTRA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R445Q	TCGA-BR-6802	STAD	TCGA	LYVTPEVT	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.1944
p.A70V	TCGA-BT-A3PK	BLCA	TCGA	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0833
p.A70V	DO44051	BLCA	ICGC	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0833
p.T90I	TCGA-D3-A5GO	SKCM	TCGA	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.25
p.T90I	DO47419	SKCM	ICGC	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.25
p.S74C	DO48314	ESCA	ICGC	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1944
p.L72Q	DO23104	LINC	ICGC	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1389
p.E97D	DO41199	UCEC	ICGC	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0556
p.L72P	SIDM00511	Small Cell Lung Carcinoma	GDSC	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1389
p.L72P	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1389
p.L72P	SIDM00867	Glioblastoma	GDSC	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1389
p.L72P	SIDM00901	Endometrial Carcinoma	GDSC	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1389
p.R442W	ACH-000982	Colon/Colorectal Cancer	CCLE	LYVTPEVT	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.1111
p.R442W	ACH-001345	Colon/Colorectal Cancer	CCLE	LYVTPEVT	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.1111
p.R442W	GP5d	large intestine	COSMIC	LYVTPEVT	DEG_SCF_FBW7_1	450:457	Mutation rewiring degron network	0.1111
p.T84P	ACH-000999	Colon/Colorectal Cancer	CCLE	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.5919
p.T84P	SNU-1040	large intestine	COSMIC	PRAQLTAVT	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.5919

Kaplan plot for HTRA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HTRA2

UniProt ID: O43464

Entrez ID: 27429

Protein name: Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HTRA2 in