DegronMD

Uniprot ID: O43464

Source protein: Serine protease HTRA2, mitochondrial

Source gene: HTRA2

Class: DEG_APCC_DBOX_1

Location: 79:87

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5844

ASA_SCORE: 63.0667

COIL: 0.6579

CONS_SCORE: 0.1174

DSS_SCORE: 0.6421

HELIX: 0.2264

FCONS_SCORE: 0.5405

RIG_SCORE: 0.7204

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A70V	TCGA-BT-A3PK	BLCA	TCGA	PRAQLTAVT	DEG_APCC_DBOX_1	0.0833
p.A70V	DO44051	BLCA	ICGC	PRAQLTAVT	DEG_APCC_DBOX_1	0.0833
p.T90I	TCGA-D3-A5GO	SKCM	TCGA	PRAQLTAVT	DEG_APCC_DBOX_1	0.25
p.T90I	DO47419	SKCM	ICGC	PRAQLTAVT	DEG_APCC_DBOX_1	0.25
p.S74C	DO48314	ESCA	ICGC	PRAQLTAVT	DEG_APCC_DBOX_1	0.1944
p.L72Q	DO23104	LINC	ICGC	PRAQLTAVT	DEG_APCC_DBOX_1	0.1389
p.E97D	DO41199	UCEC	ICGC	PRAQLTAVT	DEG_APCC_DBOX_1	0.0556
p.L72P	SIDM00511	Small Cell Lung Carcinoma	GDSC	PRAQLTAVT	DEG_APCC_DBOX_1	0.1389
p.L72P	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PRAQLTAVT	DEG_APCC_DBOX_1	0.1389
p.L72P	SIDM00867	Glioblastoma	GDSC	PRAQLTAVT	DEG_APCC_DBOX_1	0.1389
p.L72P	SIDM00901	Endometrial Carcinoma	GDSC	PRAQLTAVT	DEG_APCC_DBOX_1	0.1389
p.T84P	ACH-000999	Colon/Colorectal Cancer	CCLE	PRAQLTAVT	DEG_APCC_DBOX_1	0.5919
p.T84P	SNU-1040	large_intestine	COSMIC	PRAQLTAVT	DEG_APCC_DBOX_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43464	Serine protease HTRA2, mitochondrial	DEG_APCC_DBOX_1	79:87	PRAQLTAVT	APC,CDC20,FZR1	0.5844	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons