DegronMD

Uniprot ID: Q16643

Source protein: Drebrin

Source gene: DBN1

Class: DEG_SCF_FBW7_1

Location: 328:335

E3 ligase: FBXW7

DEGRON score: 0.9659

ASA_SCORE: 101.5375

COIL: 0.9723

CONS_SCORE: 0.3337

DSS_SCORE: 0.7776

HELIX: 0.0096

FCONS_SCORE: 0.9024

RIG_SCORE: 0.5769

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I335T	TCGA-CC-A7IH	LIHC	TCGA	MAPTPIPT	DEG_SCF_FBW7_1	0.7078
p.I335T	DO52181	LIHC	ICGC	MAPTPIPT	DEG_SCF_FBW7_1	0.7078
p.S344G	TCGA-EE-A3JB	SKCM	TCGA	MAPTPIPT	DEG_SCF_FBW7_1	0.0833
p.R338Q	TCGA-EI-6507	READ	TCGA	MAPTPIPT	DEG_SCF_FBW7_1	0.25
p.R338Q	DO36675	READ	ICGC	MAPTPIPT	DEG_SCF_FBW7_1	0.25
p.S343F	TCGA-FU-A40J	CESC	TCGA	MAPTPIPT	DEG_SCF_FBW7_1	0.5556
p.S336Y	DO222775	MELA	ICGC	MAPTPIPT	DEG_SCF_FBW7_1	0.3056
p.S338C	ACH-001402	Cervical Cancer	CCLE	MAPTPIPT	DEG_SCF_FBW7_1	0.25
p.G328A	CAPAN-1	pancreas	COSMIC	MAPTPIPT	DEG_SCF_FBW7_1	0.754
p.R338W	OC-314	ovary	COSMIC	MAPTPIPT	DEG_SCF_FBW7_1	0.25
p.R336W	OC-314	ovary	COSMIC	MAPTPIPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16643	Drebrin	DEG_SCF_FBW7_1	328:335	MAPTPIPT	FBXW7	0.9659	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons