DegronMD - Q16643(DBN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S314L	TCGA-13-1505	OV	TCGA	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation rewiring degron network	0.3056
p.F295L	TCGA-AG-A002	READ	TCGA	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation blocking ubiquitination signal	0.5278
p.A307V	TCGA-B5-A11E	UCEC	TCGA	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.6936
p.I335T	TCGA-CC-A7IH	LIHC	TCGA	MAPTPIPT	DEG_SCF_FBW7_1	328:335	Mutation altering degron motif	0.7078
p.I335T	DO52181	LIHC	ICGC	MAPTPIPT	DEG_SCF_FBW7_1	328:335	Mutation altering degron motif	0.7078
p.S344G	TCGA-EE-A3JB	SKCM	TCGA	MAPTPIPT	DEG_SCF_FBW7_1	328:335	Mutation rewiring degron network	0.0833
p.R338Q	TCGA-EI-6507	READ	TCGA	MAPTPIPT	DEG_SCF_FBW7_1	328:335	Mutation rewiring degron network	0.25
p.R338Q	DO36675	READ	ICGC	MAPTPIPT	DEG_SCF_FBW7_1	328:335	Mutation rewiring degron network	0.25
p.S343F	TCGA-FU-A40J	CESC	TCGA	MAPTPIPT	DEG_SCF_FBW7_1	328:335	Mutation blocking phosphorylation signal	0.5556
p.D311Y	TCGA-XF-AAN2	BLCA	TCGA	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.7325
p.D311Y	DO219052	BLCA	ICGC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.7325
p.F296L	DO229015	LICA	ICGC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation rewiring degron network	0.1111
p.S336Y	DO222775	MELA	ICGC	MAPTPIPT	DEG_SCF_FBW7_1	328:335	Mutation rewiring degron network	0.3056
p.S312L	DO30120	OV	ICGC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.8778
p.A305V	DO41644	UCEC	ICGC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.5825
p.R317P	SIDM00334	Endometrial Carcinoma	GDSC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation rewiring degron network	0.2222
p.R317P	SIDM00477	Esophageal Carcinoma	GDSC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation rewiring degron network	0.2222
p.R317P	SIDM00686	Endometrial Carcinoma	GDSC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation rewiring degron network	0.2222
p.R317P	SIDM01159	Other Sarcomas	GDSC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation rewiring degron network	0.2222
p.V310L	SIDM00120	Prostate Carcinoma	GDSC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.6765
p.V310L	ACH-000979	Prostate Cancer	CCLE	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.6765
p.V310L	DU-145	prostate	COSMIC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.6765
p.D309E	SIDM00120	Prostate Carcinoma	GDSC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.5647
p.D309E	ACH-000979	Prostate Cancer	CCLE	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.5647
p.D309E	DU-145	prostate	COSMIC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.5647
p.N315S	ACH-001057	Lymphoma	CCLE	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation rewiring degron network	0.2778
p.S338C	ACH-001402	Cervical Cancer	CCLE	MAPTPIPT	DEG_SCF_FBW7_1	328:335	Mutation rewiring degron network	0.25
p.G315C	NCI-H128	lung	COSMIC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation rewiring degron network	0.2778
p.P307Q	SNU-C5	large intestine	COSMIC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.7035
p.V312L	DU-145	prostate	COSMIC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.6765
p.G328A	CAPAN-1	pancreas	COSMIC	MAPTPIPT	DEG_SCF_FBW7_1	328:335	Mutation altering degron motif	0.754
p.D311E	DU-145	prostate	COSMIC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.6758
p.E302G	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation rewiring degron network	0.2778
p.L312V	SNU-1040	large intestine	COSMIC	SAGSCDVPSP	DEG_COP1_1	304:313	Mutation altering degron motif	0.6765
p.R338W	OC-314	ovary	COSMIC	MAPTPIPT	DEG_SCF_FBW7_1	328:335	Mutation rewiring degron network	0.25
p.R336W	OC-314	ovary	COSMIC	MAPTPIPT	DEG_SCF_FBW7_1	328:335	Mutation rewiring degron network	0.3056

Kaplan plot for DBN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DBN1

UniProt ID: Q16643

Entrez ID: 1627

Protein name: Drebrin (Developmentally-regulated brain protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DBN1 in