DegronMD

Uniprot ID: Q16643

Source protein: Drebrin

Source gene: DBN1

Class: DEG_COP1_1

Location: 304:313

E3 ligase: COP1

DEGRON score: 0.9971

ASA_SCORE: 76.32

COIL: 0.9241

CONS_SCORE: 0.3521

DSS_SCORE: 0.5802

HELIX: 0.0438

FCONS_SCORE: 0.9472

RIG_SCORE: 0.588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S314L	TCGA-13-1505	OV	TCGA	SAGSCDVPSP	DEG_COP1_1	0.3056
p.F295L	TCGA-AG-A002	READ	TCGA	SAGSCDVPSP	DEG_COP1_1	0.5278
p.A307V	TCGA-B5-A11E	UCEC	TCGA	SAGSCDVPSP	DEG_COP1_1	0.6936
p.D311Y	TCGA-XF-AAN2	BLCA	TCGA	SAGSCDVPSP	DEG_COP1_1	0.7325
p.D311Y	DO219052	BLCA	ICGC	SAGSCDVPSP	DEG_COP1_1	0.7325
p.F296L	DO229015	LICA	ICGC	SAGSCDVPSP	DEG_COP1_1	0.1111
p.S312L	DO30120	OV	ICGC	SAGSCDVPSP	DEG_COP1_1	0.8778
p.A305V	DO41644	UCEC	ICGC	SAGSCDVPSP	DEG_COP1_1	0.5825
p.R317P	SIDM00334	Endometrial Carcinoma	GDSC	SAGSCDVPSP	DEG_COP1_1	0.2222
p.R317P	SIDM00477	Esophageal Carcinoma	GDSC	SAGSCDVPSP	DEG_COP1_1	0.2222
p.R317P	SIDM00686	Endometrial Carcinoma	GDSC	SAGSCDVPSP	DEG_COP1_1	0.2222
p.R317P	SIDM01159	Other Sarcomas	GDSC	SAGSCDVPSP	DEG_COP1_1	0.2222
p.V310L	SIDM00120	Prostate Carcinoma	GDSC	SAGSCDVPSP	DEG_COP1_1	0.6765
p.V310L	ACH-000979	Prostate Cancer	CCLE	SAGSCDVPSP	DEG_COP1_1	0.6765
p.V310L	DU-145	prostate	COSMIC	SAGSCDVPSP	DEG_COP1_1	0.6765
p.D309E	SIDM00120	Prostate Carcinoma	GDSC	SAGSCDVPSP	DEG_COP1_1	0.5647
p.D309E	ACH-000979	Prostate Cancer	CCLE	SAGSCDVPSP	DEG_COP1_1	0.5647
p.D309E	DU-145	prostate	COSMIC	SAGSCDVPSP	DEG_COP1_1	0.5647
p.N315S	ACH-001057	Lymphoma	CCLE	SAGSCDVPSP	DEG_COP1_1	0.2778
p.G315C	NCI-H128	lung	COSMIC	SAGSCDVPSP	DEG_COP1_1	0.2778
p.P307Q	SNU-C5	large_intestine	COSMIC	SAGSCDVPSP	DEG_COP1_1	0.7035
p.V312L	DU-145	prostate	COSMIC	SAGSCDVPSP	DEG_COP1_1	0.6765
p.D311E	DU-145	prostate	COSMIC	SAGSCDVPSP	DEG_COP1_1	0.6758
p.E302G	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SAGSCDVPSP	DEG_COP1_1	0.2778
p.L312V	SNU-1040	large_intestine	COSMIC	SAGSCDVPSP	DEG_COP1_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16643	Drebrin	DEG_COP1_1	304:313	SAGSCDVPSP	COP1	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SAGSCDVPSP

Degron related mutations and impact score

Drug responses associated with DBN1 mutations

All proteins holding degron of SAGSCDVPSP