DegronMD

Uniprot ID: P0CJ72

Source protein: Humanin-like 5

Source gene: MTRNR2L5

Class: DEG_SCF_FBW7_1

Location: 1:7

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 71.7714

COIL: 0.811

CONS_SCORE: 1

DSS_SCORE: 0.6027

HELIX: 0.0154

FCONS_SCORE: 1

RIG_SCORE: 0.7896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T13S	DO225249	BRCA	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.1667
p.T13I	DO229013	COCA	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.1667
p.T13I	DO229003	COCA	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.1667
p.T13I	DO229005	COCA	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.1667
p.T13I	DO234285	ESAD	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.1667
p.T13I	DO230659	LAML	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.1667
p.T13I	DO230929	LUSC	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.1667
p.S12L	DO229030	LICA	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.1944
p.D17E	DO230979	LUSC	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.0556
p.D17E	DO224610	LUSC	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.0556
p.E15K	DO222644	MELA	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.1111
p.E15K	DO218846	SKCA	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.1111
p.E15K	DO37782	SKCM	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.1111
p.G5V	DO46909	RECA	ICGC	MATPGFS	DEG_SCF_FBW7_1	0.6421

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0CJ72	Humanin-like 5	DEG_SCF_FBW7_1	1:7	MATPGFS	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons