DegronMD

Uniprot ID: Q9UQP3

Source protein: Tenascin-N

Source gene: TNN

Class: LIG_APCC_ABBA_1

Location: 487:492

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.802

ASA_SCORE: 82.85

COIL: 0.5257

CONS_SCORE: 0.3987

DSS_SCORE: 0.4436

HELIX: 0.0193

FCONS_SCORE: 0.7992

RIG_SCORE: 0.7913

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D483H	TCGA-19-1387	GBM	TCGA	MAVHKD	LIG_APCC_ABBA_1	0.2222
p.D483H	DO11573	GBM	ICGC	MAVHKD	LIG_APCC_ABBA_1	0.2222
p.A480D	TCGA-A5-A0G2	UCEC	TCGA	MAVHKD	LIG_APCC_ABBA_1	0.1389
p.A480D	DO41235	UCEC	ICGC	MAVHKD	LIG_APCC_ABBA_1	0.1389
p.T499M	TCGA-CV-7432	HNSC	TCGA	MAVHKD	LIG_APCC_ABBA_1	0.1389
p.T499M	DO14159	HNSC	ICGC	MAVHKD	LIG_APCC_ABBA_1	0.1389
p.D483N	TCGA-D3-A3MU	SKCM	TCGA	MAVHKD	LIG_APCC_ABBA_1	0.2222
p.D483N	DO47337	SKCM	ICGC	MAVHKD	LIG_APCC_ABBA_1	0.2222
p.D481Y	TCGA-D7-A6F2	STAD	TCGA	MAVHKD	LIG_APCC_ABBA_1	0.1667
p.D481Y	DO50121	STAD	ICGC	MAVHKD	LIG_APCC_ABBA_1	0.1667
p.T496I	TCGA-EO-A22R	UCEC	TCGA	MAVHKD	LIG_APCC_ABBA_1	0.2222
p.T496I	DO42713	UCEC	ICGC	MAVHKD	LIG_APCC_ABBA_1	0.2222
p.S479F	TCGA-FS-A4F5	SKCM	TCGA	MAVHKD	LIG_APCC_ABBA_1	0.5556
p.S479F	DO37881	SKCM	ICGC	MAVHKD	LIG_APCC_ABBA_1	0.5556
p.V497L	TCGA-NC-A5HI	LUSC	TCGA	MAVHKD	LIG_APCC_ABBA_1	0.1944
p.V497L	DO45461	LUSC	ICGC	MAVHKD	LIG_APCC_ABBA_1	0.1944
p.M487I	DO231057	LUSC	ICGC	MAVHKD	LIG_APCC_ABBA_1	0.6507
p.E486K	DO220872	MELA	ICGC	MAVHKD	LIG_APCC_ABBA_1	0.3056
p.E486K	DO229446	SKCA	ICGC	MAVHKD	LIG_APCC_ABBA_1	0.3056
p.G500S	DO229453	SKCA	ICGC	MAVHKD	LIG_APCC_ABBA_1	0.1111
p.S494C	ACH-000975	Lung Cancer	CCLE	MAVHKD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQP3	Tenascin-N	LIG_APCC_ABBA_1	487:492	MAVHKD	APC,CDC20,FZR1	0.802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons