DegronMD - Q9UQP3(TNN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D483H	TCGA-19-1387	GBM	TCGA	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.2222
p.D483H	DO11573	GBM	ICGC	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.2222
p.R1021L	TCGA-21-1083	LUSC	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.R1021L	DO26769	LUSC	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.G1020A	TCGA-22-1016	LUSC	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2222
p.G1020A	DO26971	LUSC	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2222
p.A480D	TCGA-A5-A0G2	UCEC	TCGA	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.1389
p.A480D	DO41235	UCEC	ICGC	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.1389
p.M1017I	TCGA-AA-3984	COAD	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.1389
p.M1017I	DO9002	COAD	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.1389
p.M1017I	DO228952	LICA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.1389
p.A1027V	TCGA-AX-A1CE	UCEC	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation altering degron motif	0.5825
p.A1027V	DO233115	GACA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation altering degron motif	0.5825
p.A1027V	DO42280	UCEC	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation altering degron motif	0.5825
p.A1035T	TCGA-BR-8591	STAD	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.A1035T	DO47973	STAD	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.T499M	TCGA-CV-7432	HNSC	TCGA	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.1389
p.T499M	DO14159	HNSC	ICGC	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.1389
p.D483N	TCGA-D3-A3MU	SKCM	TCGA	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.2222
p.D483N	DO47337	SKCM	ICGC	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.2222
p.D481Y	TCGA-D7-A6F2	STAD	TCGA	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.1667
p.D481Y	DO50121	STAD	ICGC	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.1667
p.E1022K	TCGA-DA-A1I5	SKCM	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2778
p.E1022K	DO37447	SKCM	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2778
p.G1020E	TCGA-EE-A2M5	SKCM	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2222
p.G1020E	DO222423	MELA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2222
p.G1020E	DO37425	SKCM	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.2222
p.T496I	TCGA-EO-A22R	UCEC	TCGA	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.2222
p.T496I	DO42713	UCEC	ICGC	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.2222
p.S479F	TCGA-FS-A4F5	SKCM	TCGA	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation blocking phosphorylation signal	0.5556
p.S479F	DO37881	SKCM	ICGC	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation blocking phosphorylation signal	0.5556
p.V497L	TCGA-NC-A5HI	LUSC	TCGA	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.1944
p.V497L	DO45461	LUSC	ICGC	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.1944
p.V1042F	DO228976	LICA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.0556
p.A1035S	DO229028	LICA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.E1032D	DO229022	LICA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation altering degron motif	0.5647
p.G1030C	DO229031	LICA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation altering degron motif	0.6489
p.Q1029K	DO229052	LICA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation altering degron motif	0.5833
p.M487I	DO231057	LUSC	ICGC	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation altering degron motif	0.6507
p.E486K	DO220872	MELA	ICGC	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.3056
p.E486K	DO229446	SKCA	ICGC	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.3056
p.G500S	DO229453	SKCA	ICGC	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.1111
p.V1014I	SIDM01291	Esophageal Carcinoma	GDSC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.0556
p.L1041P	SIDM01311	Esophageal Carcinoma	GDSC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.0833
p.R1021W	SIDM01189	Glioblastoma	GDSC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.R1021W	U-87-MG	central nervous system	COSMIC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.R1021Q	SIDM00666	Glioma	GDSC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.R1021Q	ACH-000067	Brain Cancer	CCLE	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.R1021Q	Hs683	central nervous system	COSMIC	QRFALQGLE	DEG_APCC_DBOX_1	1024:1032	Mutation rewiring degron network	0.25
p.S494C	ACH-000975	Lung Cancer	CCLE	MAVHKD	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.2778

Kaplan plot for TNN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNN

UniProt ID: Q9UQP3

Entrez ID: 63923

Protein name: Tenascin-N (TN-N) (Tenascin-W) (TN-W)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNN in