DegronMD

Uniprot ID: Q9UQP3

Source protein: Tenascin-N

Source gene: TNN

Class: DEG_APCC_DBOX_1

Location: 1024:1032

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7114

ASA_SCORE: 50.6778

COIL: 0.4042

CONS_SCORE: 0.7733

DSS_SCORE: 0.3727

HELIX: 0.0189

FCONS_SCORE: 1.1494

RIG_SCORE: 0.8117

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1021L	TCGA-21-1083	LUSC	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	0.25
p.R1021L	DO26769	LUSC	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.25
p.G1020A	TCGA-22-1016	LUSC	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	0.2222
p.G1020A	DO26971	LUSC	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.2222
p.M1017I	TCGA-AA-3984	COAD	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	0.1389
p.M1017I	DO9002	COAD	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.1389
p.M1017I	DO228952	LICA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.1389
p.A1027V	TCGA-AX-A1CE	UCEC	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	0.5825
p.A1027V	DO233115	GACA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.5825
p.A1027V	DO42280	UCEC	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.5825
p.A1035T	TCGA-BR-8591	STAD	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	0.25
p.A1035T	DO47973	STAD	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.25
p.E1022K	TCGA-DA-A1I5	SKCM	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	0.2778
p.E1022K	DO37447	SKCM	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.2778
p.G1020E	TCGA-EE-A2M5	SKCM	TCGA	QRFALQGLE	DEG_APCC_DBOX_1	0.2222
p.G1020E	DO222423	MELA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.2222
p.G1020E	DO37425	SKCM	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.2222
p.V1042F	DO228976	LICA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.0556
p.A1035S	DO229028	LICA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.25
p.E1032D	DO229022	LICA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.5647
p.G1030C	DO229031	LICA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.6489
p.Q1029K	DO229052	LICA	ICGC	QRFALQGLE	DEG_APCC_DBOX_1	0.5833
p.V1014I	SIDM01291	Esophageal Carcinoma	GDSC	QRFALQGLE	DEG_APCC_DBOX_1	0.0556
p.L1041P	SIDM01311	Esophageal Carcinoma	GDSC	QRFALQGLE	DEG_APCC_DBOX_1	0.0833
p.R1021W	SIDM01189	Glioblastoma	GDSC	QRFALQGLE	DEG_APCC_DBOX_1	0.25
p.R1021W	U-87-MG	central_nervous_system	COSMIC	QRFALQGLE	DEG_APCC_DBOX_1	0.25
p.R1021Q	SIDM00666	Glioma	GDSC	QRFALQGLE	DEG_APCC_DBOX_1	0.25
p.R1021Q	ACH-000067	Brain Cancer	CCLE	QRFALQGLE	DEG_APCC_DBOX_1	0.25
p.R1021Q	Hs683	central_nervous_system	COSMIC	QRFALQGLE	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRFALQGLE

Degron related mutations and impact score

Drug responses associated with TNN mutations

All proteins holding degron of QRFALQGLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQP3	Tenascin-N	DEG_APCC_DBOX_1	1024:1032	QRFALQGLE	APC,CDC20,FZR1	0.7114	More...