DegronMD

Uniprot ID: Q5FWF4

Source protein: DNA annealing helicase and endonuclease ZRANB3

Source gene: ZRANB3

Class: DEG_SCF_FBW7_1

Location: 643:650

E3 ligase: FBXW7

DEGRON score: 0.6693

ASA_SCORE: 77.675

COIL: 0.7498

CONS_SCORE: 0.3201

DSS_SCORE: 0.2346

HELIX: 0.1445

FCONS_SCORE: 1.0603

RIG_SCORE: 0.7706

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S657N	TCGA-AP-A1E0	UCEC	TCGA	MCETPQGS	DEG_SCF_FBW7_1	0.1389
p.S657N	DO43154	UCEC	ICGC	MCETPQGS	DEG_SCF_FBW7_1	0.1389
p.P639T	TCGA-L3-A524	LUSC	TCGA	MCETPQGS	DEG_SCF_FBW7_1	0.2222
p.P639T	DO45476	LUSC	ICGC	MCETPQGS	DEG_SCF_FBW7_1	0.2222
p.E637V	DO229010	COCA	ICGC	MCETPQGS	DEG_SCF_FBW7_1	0.1667
p.E637V	DO229013	COCA	ICGC	MCETPQGS	DEG_SCF_FBW7_1	0.1667
p.E637V	DO229016	COCA	ICGC	MCETPQGS	DEG_SCF_FBW7_1	0.1667
p.E637V	DO229480	LAML	ICGC	MCETPQGS	DEG_SCF_FBW7_1	0.1667
p.E637V	DO52365	LUSC	ICGC	MCETPQGS	DEG_SCF_FBW7_1	0.1667
p.E637V	DO218852	SKCA	ICGC	MCETPQGS	DEG_SCF_FBW7_1	0.1667
p.T646A	DO231072	LUSC	ICGC	MCETPQGS	DEG_SCF_FBW7_1	0.7139
p.T646A	SIDM00290	Gastric Carcinoma	GDSC	MCETPQGS	DEG_SCF_FBW7_1	0.7139
p.T646A	SIDM00164	Biliary Tract Carcinoma	GDSC	MCETPQGS	DEG_SCF_FBW7_1	0.7139
p.T646A	SIDM01473	Plasma Cell Myeloma	GDSC	MCETPQGS	DEG_SCF_FBW7_1	0.7139
p.I633F	SIDM00483	Esophageal Carcinoma	GDSC	MCETPQGS	DEG_SCF_FBW7_1	0.0556
p.I633F	ACH-001654	Esophageal Cancer	CCLE	MCETPQGS	DEG_SCF_FBW7_1	0.0556
p.I633F	SK-GT-4	oesophagus	COSMIC	MCETPQGS	DEG_SCF_FBW7_1	0.0556
p.N659S	SIDM00068	Colorectal Carcinoma	GDSC	MCETPQGS	DEG_SCF_FBW7_1	0.0833
p.S650R	SIDM01768	Melanoma	GDSC	MCETPQGS	DEG_SCF_FBW7_1	0.7427
p.S650R	ACH-000899	Skin Cancer	CCLE	MCETPQGS	DEG_SCF_FBW7_1	0.7427
p.S636L	ACH-001396	Metastasis	CCLE	MCETPQGS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5FWF4	DNA annealing helicase and endonuclease ZRANB3	DEG_SCF_FBW7_1	643:650	MCETPQGS	FBXW7	0.6693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons