DegronMD

Uniprot ID: Q9UJY1

Source protein: Heat shock protein beta-8

Source gene: HSPB8

Class: LIG_APCC_ABBA_1

Location: 37:42

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7344

ASA_SCORE: 45.25

COIL: 0.7512

CONS_SCORE: 0.5085

DSS_SCORE: 0.354

HELIX: 0.2108

FCONS_SCORE: 0.9727

RIG_SCORE: 0.7259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P41L	TCGA-33-4532	LUSC	TCGA	MDPFPD	LIG_APCC_ABBA_1	0.6471
p.P41L	DO26626	LUSC	ICGC	MDPFPD	LIG_APCC_ABBA_1	0.6471
p.R29H	TCGA-AG-3727	READ	TCGA	MDPFPD	LIG_APCC_ABBA_1	0.1111
p.R29H	TCGA-EO-A22R	UCEC	TCGA	MDPFPD	LIG_APCC_ABBA_1	0.1111
p.R29H	DO37138	READ	ICGC	MDPFPD	LIG_APCC_ABBA_1	0.1111
p.R29H	DO42713	UCEC	ICGC	MDPFPD	LIG_APCC_ABBA_1	0.1111
p.A46T	TCGA-AX-A2HD	UCEC	TCGA	MDPFPD	LIG_APCC_ABBA_1	0.2222
p.A46T	DO42608	UCEC	ICGC	MDPFPD	LIG_APCC_ABBA_1	0.2222
p.D38E	DO230931	LUSC	ICGC	MDPFPD	LIG_APCC_ABBA_1	0.5647
p.D38E	DO224548	LUSC	ICGC	MDPFPD	LIG_APCC_ABBA_1	0.5647
p.D43N	SIDM00251	Gastric Carcinoma	GDSC	MDPFPD	LIG_APCC_ABBA_1	0.3056
p.D43N	ACH-000949	Gastric Cancer	CCLE	MDPFPD	LIG_APCC_ABBA_1	0.3056
p.D43N	TGBC11TKB	stomach	COSMIC	MDPFPD	LIG_APCC_ABBA_1	0.3056
p.D38N	ACH-002027	Endometrial/Uterine Cancer	CCLE	MDPFPD	LIG_APCC_ABBA_1	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJY1	Heat shock protein beta-8	LIG_APCC_ABBA_1	37:42	MDPFPD	APC,CDC20,FZR1	0.7344	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons