DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_2

Location: 3564:3571

E3 ligase: FBXW7

DEGRON score: 0.7394

ASA_SCORE: 98.0625

COIL: 0.9169

CONS_SCORE: 0

DSS_SCORE: 0.7353

HELIX: 0.0176

FCONS_SCORE: 0

RIG_SCORE: 0.682

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3566N	TCGA-D1-A103	UCEC	TCGA	MDSTPATE	DEG_SCF_FBW7_2	0.5958
p.S3566N	DO42312	UCEC	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.5958
p.D3565V	TCGA-DD-AADO	LIHC	TCGA	MDSTPATE	DEG_SCF_FBW7_2	0.6674
p.D3565V	DO52241	LIHC	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.6674
p.M3561I	TCGA-DK-A1AG	BLCA	TCGA	MDSTPATE	DEG_SCF_FBW7_2	0.25
p.M3561I	DO822	BLCA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.25
p.P3555H	TCGA-EE-A183	SKCM	TCGA	MDSTPATE	DEG_SCF_FBW7_2	0.0833
p.P3555H	DO37715	SKCM	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.0833
p.E3571K	TCGA-EE-A3JA	SKCM	TCGA	MDSTPATE	DEG_SCF_FBW7_2	0.7022
p.E3571K	DO47625	SKCM	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.7022
p.P3568L	TCGA-EY-A215	UCEC	TCGA	MDSTPATE	DEG_SCF_FBW7_2	0.7582
p.P3568L	DO42665	UCEC	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.7582
p.G3560S	TCGA-YC-A89H	BLCA	TCGA	MDSTPATE	DEG_SCF_FBW7_2	0.2222
p.G3560S	DO51948	BLCA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.2222
p.R3573H	DO230334	COCA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.2778
p.R3573H	DO229013	COCA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.2778
p.R3573H	DO234216	ESAD	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.2778
p.R3573H	DO229505	LAML	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.2778
p.R3573H	DO228941	LICA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.2778
p.R3573H	DO230929	LUSC	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.2778
p.R3573H	DO230974	LUSC	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.2778
p.A3569T	DO227634	COCA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.6028
p.T3563S	DO233692	GACA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.3056
p.P3568T	DO233916	GACA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.7031
p.A3569V	DO50970	LICA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.5825
p.P3580L	DO220895	MELA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.0833
p.S3576C	DO217836	ORCA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.1944
p.T3574K	DO46733	PACA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.25
p.M3564I	DO229462	SKCA	ICGC	MDSTPATE	DEG_SCF_FBW7_2	0.6507
p.T3574S	SIDM00867	Glioblastoma	GDSC	MDSTPATE	DEG_SCF_FBW7_2	0.25
p.T3574S	ACH-000863	Brain Cancer	CCLE	MDSTPATE	DEG_SCF_FBW7_2	0.25
p.T3574S	DBTRG-05MG	central_nervous_system	COSMIC	MDSTPATE	DEG_SCF_FBW7_2	0.25
p.D3565Y	ACH-000512	Myeloma	CCLE	MDSTPATE	DEG_SCF_FBW7_2	0.6214
p.E3571Q	ACH-001407	Bladder Cancer	CCLE	MDSTPATE	DEG_SCF_FBW7_2	0.6744

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MDSTPATE

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of MDSTPATE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_2	3564:3571	MDSTPATE	FBXW7	0.7394	More...