DegronMD

Uniprot ID: Q99848

Source protein: Probable rRNA-processing protein EBP2

Source gene: EBNA1BP2

Class: DEG_SCF_FBW7_1

Location: 1:7

E3 ligase: FBXW7

DEGRON score: 0.953

ASA_SCORE: 112.3429

COIL: 0.982

CONS_SCORE: 0.2559

DSS_SCORE: 0.9716

HELIX: 0.0111

FCONS_SCORE: 0.7851

RIG_SCORE: 0.6327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V8I	TCGA-AZ-4615	COAD	TCGA	MDTPPLS	DEG_SCF_FBW7_1	0.3056
p.V8I	DO7977	COAD	ICGC	MDTPPLS	DEG_SCF_FBW7_1	0.3056
p.F17L	DO233781	GACA	ICGC	MDTPPLS	DEG_SCF_FBW7_1	0.0556
p.F17L	DO229038	LICA	ICGC	MDTPPLS	DEG_SCF_FBW7_1	0.0556
p.E4K	DO220899	MELA	ICGC	MDTPPLS	DEG_SCF_FBW7_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99848	Probable rRNA-processing protein EBP2	DEG_SCF_FBW7_1	1:7	MDTPPLS	FBXW7	0.953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons