DegronMD

Uniprot ID: Q8N8V4

Source protein: Ankyrin repeat and SAM domain-containing protein 4B

Source gene: ANKS4B

Class: LIG_APCC_ABBA_1

Location: 231:236

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7635

ASA_SCORE: 50.7

COIL: 0.054

CONS_SCORE: 0.4104

DSS_SCORE: 0.5884

HELIX: 0.9408

FCONS_SCORE: 1.0043

RIG_SCORE: 0.7842

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S243L	TCGA-EE-A2MU	SKCM	TCGA	MEVFRE	LIG_APCC_ABBA_1	0.1389
p.S243L	DO37436	SKCM	ICGC	MEVFRE	LIG_APCC_ABBA_1	0.1389
p.F242L	TCGA-EO-A22R	UCEC	TCGA	MEVFRE	LIG_APCC_ABBA_1	0.1667
p.F242L	DO42713	UCEC	ICGC	MEVFRE	LIG_APCC_ABBA_1	0.1667
p.E237K	TCGA-FR-A7U9	SKCM	TCGA	MEVFRE	LIG_APCC_ABBA_1	0.3056
p.E237K	DO48546	SKCM	ICGC	MEVFRE	LIG_APCC_ABBA_1	0.3056
p.M231V	TCGA-VQ-AA6G	STAD	TCGA	MEVFRE	LIG_APCC_ABBA_1	0.6097
p.M231V	DO51801	STAD	ICGC	MEVFRE	LIG_APCC_ABBA_1	0.6097
p.R228G	SIDM00102	Mesothelioma	GDSC	MEVFRE	LIG_APCC_ABBA_1	0.25
p.R228G	SIDM00176	Chondrosarcoma	GDSC	MEVFRE	LIG_APCC_ABBA_1	0.25
p.D240G	SIDM01611	Endometrial Carcinoma	GDSC	MEVFRE	LIG_APCC_ABBA_1	0.2222
p.D240G	ACH-000996	Endometrial/Uterine Cancer	CCLE	MEVFRE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N8V4	Ankyrin repeat and SAM domain-containing protein 4B	LIG_APCC_ABBA_1	231:236	MEVFRE	APC,CDC20,FZR1	0.7635	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons