DegronMD - Q8N8V4(ANKS4B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V275A	TCGA-06-5416	GBM	TCGA	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation altering degron motif	0.5825
p.V275A	DO10880	GBM	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation altering degron motif	0.5825
p.R268C	TCGA-27-1834	GBM	TCGA	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation altering degron motif	0.8301
p.R268C	DO13300	GBM	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation altering degron motif	0.8301
p.G258S	TCGA-BQ-5877	KIRP	TCGA	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation rewiring degron network	0.0833
p.G258S	DO222794	COCA	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation rewiring degron network	0.0833
p.G258S	DO20859	KIRP	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation rewiring degron network	0.0833
p.R278S	TCGA-CR-6484	HNSC	TCGA	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation rewiring degron network	0.25
p.R278S	DO15206	HNSC	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation rewiring degron network	0.25
p.G272E	TCGA-EB-A3XC	SKCM	TCGA	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation altering degron motif	0.6087
p.G272E	DO37579	SKCM	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation altering degron motif	0.6087
p.P284L	TCGA-EE-A29D	SKCM	TCGA	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation rewiring degron network	0.0833
p.P284L	DO38123	SKCM	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation rewiring degron network	0.0833
p.S243L	TCGA-EE-A2MU	SKCM	TCGA	MEVFRE	LIG_APCC_ABBA_1	231:236	Mutation rewiring degron network	0.1389
p.S243L	DO37436	SKCM	ICGC	MEVFRE	LIG_APCC_ABBA_1	231:236	Mutation rewiring degron network	0.1389
p.F242L	TCGA-EO-A22R	UCEC	TCGA	MEVFRE	LIG_APCC_ABBA_1	231:236	Mutation rewiring degron network	0.1667
p.F242L	DO42713	UCEC	ICGC	MEVFRE	LIG_APCC_ABBA_1	231:236	Mutation rewiring degron network	0.1667
p.E237K	TCGA-FR-A7U9	SKCM	TCGA	MEVFRE	LIG_APCC_ABBA_1	231:236	Mutation rewiring degron network	0.3056
p.E237K	DO48546	SKCM	ICGC	MEVFRE	LIG_APCC_ABBA_1	231:236	Mutation rewiring degron network	0.3056
p.M231V	TCGA-VQ-AA6G	STAD	TCGA	MEVFRE	LIG_APCC_ABBA_1	231:236	Mutation altering degron motif	0.6097
p.M231V	DO51801	STAD	ICGC	MEVFRE	LIG_APCC_ABBA_1	231:236	Mutation altering degron motif	0.6097
p.R280M	DO233732	GACA	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation rewiring degron network	0.1944
p.G270V	DO229022	LICA	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation altering degron motif	0.6421
p.R268H	DO231102	LUSC	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation altering degron motif	0.8244
p.L266F	DO222908	MELA	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation rewiring degron network	0.3056
p.S264P	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation rewiring degron network	0.25
p.S264P	ACH-000365	Lymphoma	CCLE	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation rewiring degron network	0.25
p.S264P	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation rewiring degron network	0.25
p.R228G	SIDM00102	Mesothelioma	GDSC	MEVFRE	LIG_APCC_ABBA_1	231:236	Mutation rewiring degron network	0.25
p.R228G	SIDM00176	Chondrosarcoma	GDSC	MEVFRE	LIG_APCC_ABBA_1	231:236	Mutation rewiring degron network	0.25
p.R268L	SIDM00285	Neuroblastoma	GDSC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation altering degron motif	0.8428
p.R268L	ACH-001338	Neuroblastoma	CCLE	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation altering degron motif	0.8428
p.R268L	CHP-134	autonomic ganglia	COSMIC	NRPGLGSIV	DEG_APCC_DBOX_1	267:275	Mutation altering degron motif	0.8428
p.D240G	SIDM01611	Endometrial Carcinoma	GDSC	MEVFRE	LIG_APCC_ABBA_1	231:236	Mutation rewiring degron network	0.2222
p.D240G	ACH-000996	Endometrial/Uterine Cancer	CCLE	MEVFRE	LIG_APCC_ABBA_1	231:236	Mutation rewiring degron network	0.2222

Kaplan plot for ANKS4B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKS4B

UniProt ID: Q8N8V4

Entrez ID: 257629

Protein name: Ankyrin repeat and SAM domain-containing protein 4B (Harmonin-interacting ankyrin repeat-containing protein) (Harp)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKS4B in