DegronMD

Uniprot ID: Q8N8V4

Source protein: Ankyrin repeat and SAM domain-containing protein 4B

Source gene: ANKS4B

Class: DEG_APCC_DBOX_1

Location: 267:275

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9881

ASA_SCORE: 50.4889

COIL: 0.6624

CONS_SCORE: 0.5506

DSS_SCORE: 0.3354

HELIX: 0.1122

FCONS_SCORE: 1.308

RIG_SCORE: 0.7152

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V275A	TCGA-06-5416	GBM	TCGA	NRPGLGSIV	DEG_APCC_DBOX_1	0.5825
p.V275A	DO10880	GBM	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	0.5825
p.R268C	TCGA-27-1834	GBM	TCGA	NRPGLGSIV	DEG_APCC_DBOX_1	0.8301
p.R268C	DO13300	GBM	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	0.8301
p.G258S	TCGA-BQ-5877	KIRP	TCGA	NRPGLGSIV	DEG_APCC_DBOX_1	0.0833
p.G258S	DO222794	COCA	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	0.0833
p.G258S	DO20859	KIRP	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	0.0833
p.R278S	TCGA-CR-6484	HNSC	TCGA	NRPGLGSIV	DEG_APCC_DBOX_1	0.25
p.R278S	DO15206	HNSC	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	0.25
p.G272E	TCGA-EB-A3XC	SKCM	TCGA	NRPGLGSIV	DEG_APCC_DBOX_1	0.6087
p.G272E	DO37579	SKCM	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	0.6087
p.P284L	TCGA-EE-A29D	SKCM	TCGA	NRPGLGSIV	DEG_APCC_DBOX_1	0.0833
p.P284L	DO38123	SKCM	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	0.0833
p.R280M	DO233732	GACA	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	0.1944
p.G270V	DO229022	LICA	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	0.6421
p.R268H	DO231102	LUSC	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	0.8244
p.L266F	DO222908	MELA	ICGC	NRPGLGSIV	DEG_APCC_DBOX_1	0.3056
p.S264P	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRPGLGSIV	DEG_APCC_DBOX_1	0.25
p.S264P	ACH-000365	Lymphoma	CCLE	NRPGLGSIV	DEG_APCC_DBOX_1	0.25
p.S264P	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	NRPGLGSIV	DEG_APCC_DBOX_1	0.25
p.R268L	SIDM00285	Neuroblastoma	GDSC	NRPGLGSIV	DEG_APCC_DBOX_1	0.8428
p.R268L	ACH-001338	Neuroblastoma	CCLE	NRPGLGSIV	DEG_APCC_DBOX_1	0.8428
p.R268L	CHP-134	autonomic_ganglia	COSMIC	NRPGLGSIV	DEG_APCC_DBOX_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N8V4	Ankyrin repeat and SAM domain-containing protein 4B	DEG_APCC_DBOX_1	267:275	NRPGLGSIV	APC,CDC20,FZR1	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons