DegronMD

Uniprot ID: O95072

Source protein: Meiotic recombination protein REC8 homolog

Source gene: REC8

Class: DEG_SCF_FBW7_2

Location: 271:278

E3 ligase: FBXW7

DEGRON score: 0.8968

ASA_SCORE: 98.9875

COIL: 0.7941

CONS_SCORE: 0.3495

DSS_SCORE: 0.5695

HELIX: 0.1793

FCONS_SCORE: 0.9544

RIG_SCORE: 0.6973

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R279H	TCGA-AZ-6601	COAD	TCGA	MEVTPPEE	DEG_SCF_FBW7_2	0.3056
p.R279H	DO8119	COAD	ICGC	MEVTPPEE	DEG_SCF_FBW7_2	0.3056
p.R279H	DO233898	GACA	ICGC	MEVTPPEE	DEG_SCF_FBW7_2	0.3056
p.M270I	DO233109	GACA	ICGC	MEVTPPEE	DEG_SCF_FBW7_2	0.3056
p.S285R	DO233916	GACA	ICGC	MEVTPPEE	DEG_SCF_FBW7_2	0.1389
p.P266H	SIDM00683	Prostate Carcinoma	GDSC	MEVTPPEE	DEG_SCF_FBW7_2	0.1944
p.P266H	LNCaP-Clone-FGC	prostate	COSMIC	MEVTPPEE	DEG_SCF_FBW7_2	0.1944
p.P265H	ACH-000977	lymph_node	CCLE	MEVTPPEE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95072	Meiotic recombination protein REC8 homolog	DEG_SCF_FBW7_2	271:278	MEVTPPEE	FBXW7	0.8968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons