DegronMD - O95072(REC8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R301H	TCGA-19-5956	GBM	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.2778
p.R301H	DO13863	GBM	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.2778
p.I313S	TCGA-85-7710	LUSC	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.2222
p.I313S	DO26826	LUSC	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.2222
p.R299C	TCGA-A5-A0G2	UCEC	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.2222
p.R299C	DO41235	UCEC	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.2222
p.Q312R	TCGA-AP-A1DK	UCEC	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.25
p.Q312R	DO42033	UCEC	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.25
p.R279H	TCGA-AZ-6601	COAD	TCGA	MEVTPPEE	DEG_SCF_FBW7_2	271:278	Mutation rewiring degron network	0.3056
p.R279H	DO8119	COAD	ICGC	MEVTPPEE	DEG_SCF_FBW7_2	271:278	Mutation rewiring degron network	0.3056
p.R279H	DO233898	GACA	ICGC	MEVTPPEE	DEG_SCF_FBW7_2	271:278	Mutation rewiring degron network	0.3056
p.R298C	TCGA-CG-4460	STAD	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.1944
p.R298C	DO222492	COCA	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.1944
p.R298C	DO38427	STAD	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.1944
p.R298C	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.1944
p.R303Q	TCGA-D1-A103	UCEC	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation altering degron motif	0.7329
p.R303Q	DO42312	UCEC	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation altering degron motif	0.7329
p.R302H	TCGA-DU-6392	LGG	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.3056
p.R302H	DO22237	LGG	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.3056
p.E316D	TCGA-EO-A22U	UCEC	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.1389
p.E316D	DO43755	UCEC	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.1389
p.R298H	DO223039	ESCA	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.1944
p.M270I	DO233109	GACA	ICGC	MEVTPPEE	DEG_SCF_FBW7_2	271:278	Mutation rewiring degron network	0.3056
p.R303G	DO233805	GACA	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation altering degron motif	0.7568
p.S285R	DO233916	GACA	ICGC	MEVTPPEE	DEG_SCF_FBW7_2	271:278	Mutation rewiring degron network	0.1389
p.R300H	SIDM02039	Colorectal Carcinoma	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.25
p.P266H	SIDM00683	Prostate Carcinoma	GDSC	MEVTPPEE	DEG_SCF_FBW7_2	271:278	Mutation rewiring degron network	0.1944
p.P266H	LNCaP-Clone-FGC	prostate	COSMIC	MEVTPPEE	DEG_SCF_FBW7_2	271:278	Mutation rewiring degron network	0.1944
p.R304W	SIDM00947	Glioblastoma	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation altering degron motif	0.7523
p.R304W	DK-MG	central nervous system	COSMIC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation altering degron motif	0.7523
p.P296L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.1389
p.P296L	NCI-H1648	lung	COSMIC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.1389
p.R301L	SIDM00844	Burkitt's Lymphoma	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.2778
p.R301L	SIDM01409	Bladder Carcinoma	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.2778
p.R301L	SIDM01525	Acute Myeloid Leukemia	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.2778
p.R303W	ACH-000244	Brain Cancer	CCLE	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation altering degron motif	0.8634
p.R297C	ACH-000726	Esophageal Cancer	CCLE	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.1667
p.P295L	ACH-000766	Lung Cancer	CCLE	RRLLFWD	LIG_APCC_ABBAyCdc20_2	303:309	Mutation rewiring degron network	0.1111
p.P265H	ACH-000977	lymph node	CCLE	MEVTPPEE	DEG_SCF_FBW7_2	271:278	Mutation rewiring degron network	0.1667

Kaplan plot for REC8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

REC8

UniProt ID: O95072

Entrez ID: 9985

Protein name: Meiotic recombination protein REC8 homolog (Cohesin Rec8p)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for REC8 in