DegronMD

Uniprot ID: O95072

Source protein: Meiotic recombination protein REC8 homolog

Source gene: REC8

Class: LIG_APCC_ABBAyCdc20_2

Location: 303:309

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7744

ASA_SCORE: 114.4571

COIL: 0.7101

CONS_SCORE: 0.4879

DSS_SCORE: 0.5417

HELIX: 0.1479

FCONS_SCORE: 1.1519

RIG_SCORE: 0.7748

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R301H	TCGA-19-5956	GBM	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R301H	DO13863	GBM	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.2778
p.I313S	TCGA-85-7710	LUSC	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.2222
p.I313S	DO26826	LUSC	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R299C	TCGA-A5-A0G2	UCEC	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R299C	DO41235	UCEC	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q312R	TCGA-AP-A1DK	UCEC	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.25
p.Q312R	DO42033	UCEC	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.25
p.R298C	TCGA-CG-4460	STAD	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R298C	DO222492	COCA	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R298C	DO38427	STAD	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R298C	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R303Q	TCGA-D1-A103	UCEC	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R303Q	DO42312	UCEC	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R302H	TCGA-DU-6392	LGG	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R302H	DO22237	LGG	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E316D	TCGA-EO-A22U	UCEC	TCGA	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E316D	DO43755	UCEC	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R298H	DO223039	ESCA	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R303G	DO233805	GACA	ICGC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.7568
p.R300H	SIDM02039	Colorectal Carcinoma	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.25
p.R304W	SIDM00947	Glioblastoma	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.7523
p.R304W	DK-MG	central_nervous_system	COSMIC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.7523
p.P296L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P296L	NCI-H1648	lung	COSMIC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R301L	SIDM00844	Burkitt's Lymphoma	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R301L	SIDM01409	Bladder Carcinoma	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R301L	SIDM01525	Acute Myeloid Leukemia	GDSC	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R303W	ACH-000244	Brain Cancer	CCLE	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.8634
p.R297C	ACH-000726	Esophageal Cancer	CCLE	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P295L	ACH-000766	Lung Cancer	CCLE	RRLLFWD	LIG_APCC_ABBAyCdc20_2	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRLLFWD

Degron related mutations and impact score

Drug responses associated with REC8 mutations

All proteins holding degron of RRLLFWD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95072	Meiotic recombination protein REC8 homolog	LIG_APCC_ABBAyCdc20_2	303:309	RRLLFWD	APC,CDC20,FZR1	0.7744	More...