DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 1825:1832

E3 ligase: FBXW7

DEGRON score: 0.8273

ASA_SCORE: 99.925

COIL: 0.8311

CONS_SCORE: 0

DSS_SCORE: 0.4946

HELIX: 0.0278

FCONS_SCORE: 0

RIG_SCORE: 0.7868

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1826V	TCGA-55-7994	LUAD	TCGA	MEVTPWIS	DEG_SCF_FBW7_1	0.6582
p.E1826V	DO45311	LUAD	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.6582
p.T1841I	TCGA-AA-A01I	COAD	TCGA	MEVTPWIS	DEG_SCF_FBW7_1	0.0833
p.T1841I	DO10510	COAD	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.0833
p.L1835R	TCGA-D1-A16X	UCEC	TCGA	MEVTPWIS	DEG_SCF_FBW7_1	0.25
p.L1835R	DO41799	UCEC	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.25
p.M1825L	TCGA-EY-A1G8	UCEC	TCGA	MEVTPWIS	DEG_SCF_FBW7_1	0.5999
p.M1825L	DO43578	UCEC	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.5999
p.S1832C	TCGA-K4-A54R	BLCA	TCGA	MEVTPWIS	DEG_SCF_FBW7_1	0.7541
p.S1832C	DO48611	BLCA	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.7541
p.L1833F	DO229010	COCA	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.3056
p.L1833F	DO229016	COCA	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.3056
p.L1833F	DO229003	COCA	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.3056
p.L1833F	DO229005	COCA	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.3056
p.L1833F	DO234285	ESAD	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.3056
p.L1833F	DO229047	LICA	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.3056
p.L1833F	DO52365	LUSC	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.3056
p.T1834I	DO229048	LICA	ICGC	MEVTPWIS	DEG_SCF_FBW7_1	0.2778
p.A1838T	SIDM00915	Small Cell Lung Carcinoma	GDSC	MEVTPWIS	DEG_SCF_FBW7_1	0.1667
p.A1838T	ACH-002173	Lung Cancer	CCLE	MEVTPWIS	DEG_SCF_FBW7_1	0.1667
p.A1838T	NCI-H378	lung	COSMIC	MEVTPWIS	DEG_SCF_FBW7_1	0.1667
p.D1817N	SIDM01060	Melanoma	GDSC	MEVTPWIS	DEG_SCF_FBW7_1	0.1111
p.D1817N	ACH-000882	Skin Cancer	CCLE	MEVTPWIS	DEG_SCF_FBW7_1	0.1111
p.D1817N	IGR-1	skin	COSMIC	MEVTPWIS	DEG_SCF_FBW7_1	0.1111
p.P1829S	SIDM00217	Colorectal Carcinoma	GDSC	MEVTPWIS	DEG_SCF_FBW7_1	0.6752
p.P1829S	ACH-000999	Colon/Colorectal Cancer	CCLE	MEVTPWIS	DEG_SCF_FBW7_1	0.6752
p.P1829S	SNU-1040	large_intestine	COSMIC	MEVTPWIS	DEG_SCF_FBW7_1	0.6752
p.S1832F	SIDM01059	Melanoma	GDSC	MEVTPWIS	DEG_SCF_FBW7_1	0.7982
p.S1832F	ACH-000915	Skin Cancer	CCLE	MEVTPWIS	DEG_SCF_FBW7_1	0.7982
p.S1832F	IPC-298	skin	COSMIC	MEVTPWIS	DEG_SCF_FBW7_1	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MEVTPWIS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of MEVTPWIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	1825:1832	MEVTPWIS	FBXW7	0.8273	More...