DegronMD

Uniprot ID: A6NGH7

Source protein: Coiled-coil domain-containing protein 160

Source gene: CCDC160

Class: DEG_SCF_FBW7_1

Location: 12:18

E3 ligase: FBXW7

DEGRON score: 0.7566

ASA_SCORE: 41.2286

COIL: 0.7591

CONS_SCORE: 0.6243

DSS_SCORE: 0.4346

HELIX: 0.053

FCONS_SCORE: 1.0356

RIG_SCORE: 0.7825

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R5K	TCGA-05-4396	LUAD	TCGA	MFTPFFS	DEG_SCF_FBW7_1	0.1389
p.R5K	DO23838	LUAD	ICGC	MFTPFFS	DEG_SCF_FBW7_1	0.1389
p.K9N	TCGA-AP-A056	UCEC	TCGA	MFTPFFS	DEG_SCF_FBW7_1	0.3611
p.K9N	DO43971	UCEC	ICGC	MFTPFFS	DEG_SCF_FBW7_1	0.3611
p.E10K	TCGA-EE-A2GO	SKCM	TCGA	MFTPFFS	DEG_SCF_FBW7_1	0.2778
p.E10K	DO37823	SKCM	ICGC	MFTPFFS	DEG_SCF_FBW7_1	0.2778
p.R5I	TCGA-EO-A22X	UCEC	TCGA	MFTPFFS	DEG_SCF_FBW7_1	0.1389
p.R5I	TCGA-EO-A3AV	UCEC	TCGA	MFTPFFS	DEG_SCF_FBW7_1	0.1389
p.R5I	DO52412	UCEC	ICGC	MFTPFFS	DEG_SCF_FBW7_1	0.1389
p.R5I	DO43907	UCEC	ICGC	MFTPFFS	DEG_SCF_FBW7_1	0.1389
p.S27Y	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	MFTPFFS	DEG_SCF_FBW7_1	0.0833
p.S27Y	ACH-000030	Lung Cancer	CCLE	MFTPFFS	DEG_SCF_FBW7_1	0.0833
p.S27Y	ACH-000779	Lung Cancer	CCLE	MFTPFFS	DEG_SCF_FBW7_1	0.0833
p.S27Y	PC-14	lung	COSMIC	MFTPFFS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NGH7	Coiled-coil domain-containing protein 160	DEG_SCF_FBW7_1	12:18	MFTPFFS	FBXW7	0.7566	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons