DegronMD

Uniprot ID: A6NGG8

Source protein: Photoreceptor cilium actin regulator

Source gene: PCARE

Class: DEG_SCF_FBW7_1

Location: 1:8

E3 ligase: FBXW7

DEGRON score: 0.9854

ASA_SCORE: 57.125

COIL: 0.744

CONS_SCORE: 0.9194

DSS_SCORE: 0.7607

HELIX: 0.171

FCONS_SCORE: 1.2642

RIG_SCORE: 0.6806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S8G	SIDM01090	Colorectal Carcinoma	GDSC	MGCTPSHS	DEG_SCF_FBW7_1	0.8104
p.S8G	RKO	large_intestine	COSMIC	MGCTPSHS	DEG_SCF_FBW7_1	0.8104
p.D9E	SIDM00789	Colorectal Carcinoma	GDSC	MGCTPSHS	DEG_SCF_FBW7_1	0.3056
p.D9E	HCT-15	large_intestine	COSMIC	MGCTPSHS	DEG_SCF_FBW7_1	0.3056
p.P5A	SIDM00761	Small Cell Lung Carcinoma	GDSC	MGCTPSHS	DEG_SCF_FBW7_1	0.7503
p.P5A	NCI-H196	lung	COSMIC	MGCTPSHS	DEG_SCF_FBW7_1	0.7503
p.G18V	SIDM01442	Glioma	GDSC	MGCTPSHS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NGG8	Photoreceptor cilium actin regulator	DEG_SCF_FBW7_1	1:8	MGCTPSHS	FBXW7	0.9854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons