DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MGLFME
Uniprot ID:
Q5T0F9
Source protein:
Coiled-coil and C2 domain-containing protein 1B
Source gene:
CC2D1B
Class:
LIG_APCC_ABBA_1
Location:
24:29
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9487
ASA_SCORE:
61.6333
COIL:
0.8663
CONS_SCORE:
0.2707
DSS_SCORE:
0.4443
HELIX:
0.0628
FCONS_SCORE:
0.9807
RIG_SCORE:
0.7617
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.M28I
TCGA-60-2710
LUSC
TCGA
MGLFME
LIG_APCC_ABBA_1
0.6507
p.M28I
DO26938
LUSC
ICGC
MGLFME
LIG_APCC_ABBA_1
0.6507
p.E33Q
TCGA-60-2721
LUSC
TCGA
MGLFME
LIG_APCC_ABBA_1
0.2222
p.E33Q
DO26447
LUSC
ICGC
MGLFME
LIG_APCC_ABBA_1
0.2222
p.L36V
TCGA-91-6835
LUAD
TCGA
MGLFME
LIG_APCC_ABBA_1
0.1389
p.L36V
DO26082
LUAD
ICGC
MGLFME
LIG_APCC_ABBA_1
0.1389
p.G15C
TCGA-AP-A1DK
UCEC
TCGA
MGLFME
LIG_APCC_ABBA_1
0.0833
p.G15C
DO42033
UCEC
ICGC
MGLFME
LIG_APCC_ABBA_1
0.0833
p.L37M
TCGA-CD-A4MJ
STAD
TCGA
MGLFME
LIG_APCC_ABBA_1
0.1111
p.L37M
DO47811
STAD
ICGC
MGLFME
LIG_APCC_ABBA_1
0.1111
p.G17V
TCGA-D3-A2JP
SKCM
TCGA
MGLFME
LIG_APCC_ABBA_1
0.1389
p.G17V
DO47407
SKCM
ICGC
MGLFME
LIG_APCC_ABBA_1
0.1389
p.K22N
TCGA-ZB-A966
THYM
TCGA
MGLFME
LIG_APCC_ABBA_1
0.2778
p.M35T
DO234203
ESAD
ICGC
MGLFME
LIG_APCC_ABBA_1
0.1667
p.G38D
DO228972
LICA
ICGC
MGLFME
LIG_APCC_ABBA_1
0.0833
p.A21G
DO48972
PBCA
ICGC
MGLFME
LIG_APCC_ABBA_1
0.25
p.V18M
SIDM00629
Breast Carcinoma
GDSC
MGLFME
LIG_APCC_ABBA_1
0.1667
p.M35I
SIDM00557
Neuroblastoma
GDSC
MGLFME
LIG_APCC_ABBA_1
0.1667
p.M35I
SIDM00215
Colorectal Carcinoma
GDSC
MGLFME
LIG_APCC_ABBA_1
0.1667
p.M35I
SIDM00585
Hepatocellular Carcinoma
GDSC
MGLFME
LIG_APCC_ABBA_1
0.1667
p.M35I
SIDM01210
Glioblastoma
GDSC
MGLFME
LIG_APCC_ABBA_1
0.1667
p.M35I
SIDM01735
Biliary Tract Carcinoma
GDSC
MGLFME
LIG_APCC_ABBA_1
0.1667
p.M35I
SIDM01444
Glioblastoma
GDSC
MGLFME
LIG_APCC_ABBA_1
0.1667
p.M35I
SIDM01443
Gastric Carcinoma
GDSC
MGLFME
LIG_APCC_ABBA_1
0.1667
Drug responses associated with CC2D1B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MGLFME
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5T0F9
Coiled-coil and C2 domain-containing protein 1B
LIG_APCC_ABBA_1
24:29
MGLFME
APC,CDC20,FZR1
0.9487
More...