DegronMD

Uniprot ID: Q5T0F9

Source protein: Coiled-coil and C2 domain-containing protein 1B

Source gene: CC2D1B

Class: LIG_APCC_ABBA_1

Location: 24:29

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9487

ASA_SCORE: 61.6333

COIL: 0.8663

CONS_SCORE: 0.2707

DSS_SCORE: 0.4443

HELIX: 0.0628

FCONS_SCORE: 0.9807

RIG_SCORE: 0.7617

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M28I	TCGA-60-2710	LUSC	TCGA	MGLFME	LIG_APCC_ABBA_1	0.6507
p.M28I	DO26938	LUSC	ICGC	MGLFME	LIG_APCC_ABBA_1	0.6507
p.K22N	TCGA-ZB-A966	THYM	TCGA	MGLFME	LIG_APCC_ABBA_1	0.2778
p.A21G	DO48972	PBCA	ICGC	MGLFME	LIG_APCC_ABBA_1	0.25
p.E33Q	TCGA-60-2721	LUSC	TCGA	MGLFME	LIG_APCC_ABBA_1	0.2222
p.E33Q	DO26447	LUSC	ICGC	MGLFME	LIG_APCC_ABBA_1	0.2222
p.M35T	DO234203	ESAD	ICGC	MGLFME	LIG_APCC_ABBA_1	0.1667
p.V18M	SIDM00629	Breast Carcinoma	GDSC	MGLFME	LIG_APCC_ABBA_1	0.1667
p.M35I	SIDM00557	Neuroblastoma	GDSC	MGLFME	LIG_APCC_ABBA_1	0.1667
p.M35I	SIDM00215	Colorectal Carcinoma	GDSC	MGLFME	LIG_APCC_ABBA_1	0.1667
p.M35I	SIDM00585	Hepatocellular Carcinoma	GDSC	MGLFME	LIG_APCC_ABBA_1	0.1667
p.M35I	SIDM01210	Glioblastoma	GDSC	MGLFME	LIG_APCC_ABBA_1	0.1667
p.M35I	SIDM01735	Biliary Tract Carcinoma	GDSC	MGLFME	LIG_APCC_ABBA_1	0.1667
p.M35I	SIDM01444	Glioblastoma	GDSC	MGLFME	LIG_APCC_ABBA_1	0.1667
p.M35I	SIDM01443	Gastric Carcinoma	GDSC	MGLFME	LIG_APCC_ABBA_1	0.1667
p.L36V	TCGA-91-6835	LUAD	TCGA	MGLFME	LIG_APCC_ABBA_1	0.1389
p.L36V	DO26082	LUAD	ICGC	MGLFME	LIG_APCC_ABBA_1	0.1389
p.G17V	TCGA-D3-A2JP	SKCM	TCGA	MGLFME	LIG_APCC_ABBA_1	0.1389
p.G17V	DO47407	SKCM	ICGC	MGLFME	LIG_APCC_ABBA_1	0.1389
p.L37M	TCGA-CD-A4MJ	STAD	TCGA	MGLFME	LIG_APCC_ABBA_1	0.1111
p.L37M	DO47811	STAD	ICGC	MGLFME	LIG_APCC_ABBA_1	0.1111
p.G15C	TCGA-AP-A1DK	UCEC	TCGA	MGLFME	LIG_APCC_ABBA_1	0.0833
p.G15C	DO42033	UCEC	ICGC	MGLFME	LIG_APCC_ABBA_1	0.0833
p.G38D	DO228972	LICA	ICGC	MGLFME	LIG_APCC_ABBA_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T0F9	Coiled-coil and C2 domain-containing protein 1B	LIG_APCC_ABBA_1	24:29	MGLFME	APC,CDC20,FZR1	0.9487	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons