DegronMD - Q5T0F9(CC2D1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R534W	TCGA-13-0905	OV	TCGA	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation altering degron motif	0.8634
p.R534W	TCGA-AP-A1DV	UCEC	TCGA	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation altering degron motif	0.8634
p.R534W	DO31490	OV	ICGC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation altering degron motif	0.8634
p.R534W	DO43186	UCEC	ICGC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation altering degron motif	0.8634
p.R534W	SIDM00780	Colorectal Carcinoma	GDSC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation altering degron motif	0.8634
p.R534W	ACH-000967	Colon/Colorectal Cancer	CCLE	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation altering degron motif	0.8634
p.M28I	TCGA-60-2710	LUSC	TCGA	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation altering degron motif	0.6507
p.M28I	DO26938	LUSC	ICGC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation altering degron motif	0.6507
p.E33Q	TCGA-60-2721	LUSC	TCGA	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.2222
p.E33Q	DO26447	LUSC	ICGC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.2222
p.L36V	TCGA-91-6835	LUAD	TCGA	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1389
p.L36V	DO26082	LUAD	ICGC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1389
p.G15C	TCGA-AP-A1DK	UCEC	TCGA	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.0833
p.G15C	DO42033	UCEC	ICGC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.0833
p.L37M	TCGA-CD-A4MJ	STAD	TCGA	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1111
p.L37M	DO47811	STAD	ICGC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1111
p.R549W	TCGA-CK-4951	COAD	TCGA	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation rewiring degron network	0.1111
p.R549W	DO10582	COAD	ICGC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation rewiring degron network	0.1111
p.G17V	TCGA-D3-A2JP	SKCM	TCGA	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1389
p.G17V	DO47407	SKCM	ICGC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1389
p.K22N	TCGA-ZB-A966	THYM	TCGA	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.2778
p.M35T	DO234203	ESAD	ICGC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1667
p.G38D	DO228972	LICA	ICGC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.0833
p.R543Q	DO35140	PACA	ICGC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation rewiring degron network	0.2778
p.R543Q	SIDM01033	Bladder Carcinoma	GDSC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation rewiring degron network	0.2778
p.R543Q	KU-19-19	urinary tract	COSMIC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation rewiring degron network	0.2778
p.A21G	DO48972	PBCA	ICGC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.25
p.K526E	DO229245	THCA	ICGC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation substituting flanking lysine	0.25
p.V18M	SIDM00629	Breast Carcinoma	GDSC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1667
p.M35I	SIDM00557	Neuroblastoma	GDSC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1667
p.M35I	SIDM00215	Colorectal Carcinoma	GDSC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1667
p.M35I	SIDM00585	Hepatocellular Carcinoma	GDSC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1667
p.M35I	SIDM01210	Glioblastoma	GDSC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1667
p.M35I	SIDM01735	Biliary Tract Carcinoma	GDSC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1667
p.M35I	SIDM01444	Glioblastoma	GDSC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1667
p.M35I	SIDM01443	Gastric Carcinoma	GDSC	MGLFME	LIG_APCC_ABBA_1	24:29	Mutation rewiring degron network	0.1667
p.L537M	SIDM00079	Ovarian Carcinoma	GDSC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation altering degron motif	0.711
p.L537M	ACH-000811	Ovarian Cancer	CCLE	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation altering degron motif	0.711
p.L537M	SK-OV-3	ovary	COSMIC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation altering degron motif	0.711
p.E527G	SIDM00591	Oral Cavity Carcinoma	GDSC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation rewiring degron network	0.1667
p.E527G	ACH-002045	Head and Neck Cancer	CCLE	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation rewiring degron network	0.1667
p.E527G	HO-1-u-1	upper aerodigestive tract	COSMIC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation rewiring degron network	0.1667
p.Q548E	ACH-001412	Bladder Cancer	CCLE	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation rewiring degron network	0.1389
p.K549M	SCC90	upper aerodigestive tract	COSMIC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation rewiring degron network	0.1111
p.L531M	SK-OV-3	ovary	COSMIC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation rewiring degron network	0.2778
p.R537Q	KU-19-19	urinary tract	COSMIC	VREQLALLE	DEG_APCC_DBOX_1	533:541	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CC2D1B

UniProt ID: Q5T0F9

Entrez ID: 200014

Protein name: Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CC2D1B in