DegronMD

Uniprot ID: Q5T0F9

Source protein: Coiled-coil and C2 domain-containing protein 1B

Source gene: CC2D1B

Class: DEG_APCC_DBOX_1

Location: 533:541

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9526

ASA_SCORE: 74.3

COIL: 0.0871

CONS_SCORE: 0.414

DSS_SCORE: 0.4853

HELIX: 0.9112

FCONS_SCORE: 1.0892

RIG_SCORE: 0.7525

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R534W	TCGA-13-0905	OV	TCGA	VREQLALLE	DEG_APCC_DBOX_1	0.8634
p.R534W	TCGA-AP-A1DV	UCEC	TCGA	VREQLALLE	DEG_APCC_DBOX_1	0.8634
p.R534W	DO31490	OV	ICGC	VREQLALLE	DEG_APCC_DBOX_1	0.8634
p.R534W	DO43186	UCEC	ICGC	VREQLALLE	DEG_APCC_DBOX_1	0.8634
p.R534W	SIDM00780	Colorectal Carcinoma	GDSC	VREQLALLE	DEG_APCC_DBOX_1	0.8634
p.R534W	ACH-000967	Colon/Colorectal Cancer	CCLE	VREQLALLE	DEG_APCC_DBOX_1	0.8634
p.R549W	TCGA-CK-4951	COAD	TCGA	VREQLALLE	DEG_APCC_DBOX_1	0.1111
p.R549W	DO10582	COAD	ICGC	VREQLALLE	DEG_APCC_DBOX_1	0.1111
p.R543Q	DO35140	PACA	ICGC	VREQLALLE	DEG_APCC_DBOX_1	0.2778
p.R543Q	SIDM01033	Bladder Carcinoma	GDSC	VREQLALLE	DEG_APCC_DBOX_1	0.2778
p.R543Q	KU-19-19	urinary_tract	COSMIC	VREQLALLE	DEG_APCC_DBOX_1	0.2778
p.K526E	DO229245	THCA	ICGC	VREQLALLE	DEG_APCC_DBOX_1	0.25
p.L537M	SIDM00079	Ovarian Carcinoma	GDSC	VREQLALLE	DEG_APCC_DBOX_1	0.711
p.L537M	ACH-000811	Ovarian Cancer	CCLE	VREQLALLE	DEG_APCC_DBOX_1	0.711
p.L537M	SK-OV-3	ovary	COSMIC	VREQLALLE	DEG_APCC_DBOX_1	0.711
p.E527G	SIDM00591	Oral Cavity Carcinoma	GDSC	VREQLALLE	DEG_APCC_DBOX_1	0.1667
p.E527G	ACH-002045	Head and Neck Cancer	CCLE	VREQLALLE	DEG_APCC_DBOX_1	0.1667
p.E527G	HO-1-u-1	upper_aerodigestive_tract	COSMIC	VREQLALLE	DEG_APCC_DBOX_1	0.1667
p.Q548E	ACH-001412	Bladder Cancer	CCLE	VREQLALLE	DEG_APCC_DBOX_1	0.1389
p.K549M	SCC90	upper_aerodigestive_tract	COSMIC	VREQLALLE	DEG_APCC_DBOX_1	0.1111
p.L531M	SK-OV-3	ovary	COSMIC	VREQLALLE	DEG_APCC_DBOX_1	0.2778
p.R537Q	KU-19-19	urinary_tract	COSMIC	VREQLALLE	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T0F9	Coiled-coil and C2 domain-containing protein 1B	DEG_APCC_DBOX_1	533:541	VREQLALLE	APC,CDC20,FZR1	0.9526	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons