DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MGPHSD
Uniprot ID:
Q4FZB7
Source protein:
Histone-lysine N-methyltransferase KMT5B
Source gene:
KMT5B
Class:
LIG_APCC_ABBA_1
Location:
646:651
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9107
ASA_SCORE:
80.7167
COIL:
0.8417
CONS_SCORE:
0.2999
DSS_SCORE:
0.7237
HELIX:
0.081
FCONS_SCORE:
0.8783
RIG_SCORE:
0.5872
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with KMT5B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MGPHSD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q4FZB7
Histone-lysine N-methyltransferase KMT5B
LIG_APCC_ABBA_1
646:651
MGPHSD
APC,CDC20,FZR1
0.9107
More...