DegronMD

Uniprot ID: Q8NAM6

Source protein: Zinc finger and SCAN domain-containing protein 4

Source gene: ZSCAN4

Class: DEG_SCF_FBW7_1

Location: 171:177

E3 ligase: FBXW7

DEGRON score: 0.9474

ASA_SCORE: 86.0429

COIL: 0.8843

CONS_SCORE: 0.5438

DSS_SCORE: 0.7282

HELIX: 0.0749

FCONS_SCORE: 1.0884

RIG_SCORE: 0.6272

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T177A	TCGA-66-2756	LUSC	TCGA	MGTPSQT	DEG_SCF_FBW7_1	0.7139
p.T177A	DO27128	LUSC	ICGC	MGTPSQT	DEG_SCF_FBW7_1	0.7139
p.Q164H	TCGA-BR-7723	STAD	TCGA	MGTPSQT	DEG_SCF_FBW7_1	0.1389
p.Q164H	DO38875	STAD	ICGC	MGTPSQT	DEG_SCF_FBW7_1	0.1389
p.S182F	TCGA-D3-A8GM	SKCM	TCGA	MGTPSQT	DEG_SCF_FBW7_1	0.1944
p.S182F	DO229177	LMS	ICGC	MGTPSQT	DEG_SCF_FBW7_1	0.1944
p.S182F	DO50288	SKCM	ICGC	MGTPSQT	DEG_SCF_FBW7_1	0.1944
p.S182F	SIDM00007	Other Solid Cancers	GDSC	MGTPSQT	DEG_SCF_FBW7_1	0.1944
p.S182F	ACH-001550	Skin Cancer	CCLE	MGTPSQT	DEG_SCF_FBW7_1	0.1944
p.S182F	MCC13	skin	COSMIC	MGTPSQT	DEG_SCF_FBW7_1	0.1944
p.M171K	DO222421	BTCA	ICGC	MGTPSQT	DEG_SCF_FBW7_1	0.8062
p.D180H	DO48274	ESCA	ICGC	MGTPSQT	DEG_SCF_FBW7_1	0.25
p.P174S	DO50970	LICA	ICGC	MGTPSQT	DEG_SCF_FBW7_1	0.6752
p.S178Y	DO23316	LINC	ICGC	MGTPSQT	DEG_SCF_FBW7_1	0.3056
p.G186R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	MGTPSQT	DEG_SCF_FBW7_1	0.0833
p.G186R	ACH-000981	Leukemia	CCLE	MGTPSQT	DEG_SCF_FBW7_1	0.0833
p.G186R	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	MGTPSQT	DEG_SCF_FBW7_1	0.0833
p.D180G	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	MGTPSQT	DEG_SCF_FBW7_1	0.25
p.D180G	ACH-000951	Lung Cancer	CCLE	MGTPSQT	DEG_SCF_FBW7_1	0.25
p.D180G	NCI-H2342	lung	COSMIC	MGTPSQT	DEG_SCF_FBW7_1	0.25
p.P174T	SIDM00863	Burkitt's Lymphoma	GDSC	MGTPSQT	DEG_SCF_FBW7_1	0.7031
p.P174T	ACH-000877	Lymphoma	CCLE	MGTPSQT	DEG_SCF_FBW7_1	0.7031
p.P174T	ACH-001064	Lymphoma	CCLE	MGTPSQT	DEG_SCF_FBW7_1	0.7031
p.P174T	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	MGTPSQT	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NAM6	Zinc finger and SCAN domain-containing protein 4	DEG_SCF_FBW7_1	171:177	MGTPSQT	FBXW7	0.9474	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons