DegronMD - Q8NAM6(ZSCAN4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P427S	TCGA-13-2057	OV	TCGA	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.5641
p.P427S	DO31320	OV	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.5641
p.E419K	TCGA-33-6737	LUSC	TCGA	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1389
p.E419K	DO48290	ESCA	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1389
p.E419K	DO26866	LUSC	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.1389
p.T177A	TCGA-66-2756	LUSC	TCGA	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation altering degron motif	0.7139
p.T177A	DO27128	LUSC	ICGC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation altering degron motif	0.7139
p.Q164H	TCGA-BR-7723	STAD	TCGA	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.1389
p.Q164H	DO38875	STAD	ICGC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.1389
p.S433F	TCGA-D3-A8GI	SKCM	TCGA	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.7982
p.S433F	DO50284	SKCM	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.7982
p.S182F	TCGA-D3-A8GM	SKCM	TCGA	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.1944
p.S182F	DO229177	LMS	ICGC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.1944
p.S182F	DO50288	SKCM	ICGC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.1944
p.S182F	SIDM00007	Other Solid Cancers	GDSC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.1944
p.S182F	ACH-001550	Skin Cancer	CCLE	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.1944
p.S182F	MCC13	skin	COSMIC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.1944
p.T429I	TCGA-D5-6540	COAD	TCGA	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.7078
p.T429I	DO9708	COAD	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.7078
p.E431K	TCGA-FW-A3R5	SKCM	TCGA	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.591
p.E431K	DO37406	SKCM	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.591
p.S428C	DO225367	BRCA	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.643
p.M171K	DO222421	BTCA	ICGC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation altering degron motif	0.8062
p.R416S	DO52455	COCA	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation rewiring degron network	0.0556
p.D180H	DO48274	ESCA	ICGC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.25
p.P174S	DO50970	LICA	ICGC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation altering degron motif	0.6752
p.S178Y	DO23316	LINC	ICGC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.3056
p.G186R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.0833
p.G186R	ACH-000981	Leukemia	CCLE	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.0833
p.G186R	DND-41	haematopoietic and lymphoid tissue	COSMIC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.0833
p.D180G	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.25
p.D180G	ACH-000951	Lung Cancer	CCLE	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.25
p.D180G	NCI-H2342	lung	COSMIC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation rewiring degron network	0.25
p.P174T	SIDM00863	Burkitt's Lymphoma	GDSC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation altering degron motif	0.7031
p.P174T	ACH-000877	Lymphoma	CCLE	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation altering degron motif	0.7031
p.P174T	ACH-001064	Lymphoma	CCLE	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation altering degron motif	0.7031
p.P174T	EB2	haematopoietic and lymphoid tissue	COSMIC	MGTPSQT	DEG_SCF_FBW7_1	171:177	Mutation altering degron motif	0.7031
p.V426I	ACH-001607	Gallbladder Cancer	CCLE	VPSTPEAS	DEG_SCF_FBW7_1	426:433	Mutation altering degron motif	0.5965

Kaplan plot for ZSCAN4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZSCAN4

UniProt ID: Q8NAM6

Entrez ID: 201516

Protein name: Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZSCAN4 in