DegronMD

Uniprot ID: Q8NAM6

Source protein: Zinc finger and SCAN domain-containing protein 4

Source gene: ZSCAN4

Class: DEG_SCF_FBW7_1

Location: 426:433

E3 ligase: FBXW7

DEGRON score: 0.5522

ASA_SCORE: 83.7625

COIL: 0.9243

CONS_SCORE: 0.2115

DSS_SCORE: 0.8677

HELIX: 0.0219

FCONS_SCORE: 0.626

RIG_SCORE: 0.6318

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P427S	TCGA-13-2057	OV	TCGA	VPSTPEAS	DEG_SCF_FBW7_1	0.5641
p.P427S	DO31320	OV	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	0.5641
p.E419K	TCGA-33-6737	LUSC	TCGA	VPSTPEAS	DEG_SCF_FBW7_1	0.1389
p.E419K	DO48290	ESCA	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	0.1389
p.E419K	DO26866	LUSC	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	0.1389
p.S433F	TCGA-D3-A8GI	SKCM	TCGA	VPSTPEAS	DEG_SCF_FBW7_1	0.7982
p.S433F	DO50284	SKCM	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	0.7982
p.T429I	TCGA-D5-6540	COAD	TCGA	VPSTPEAS	DEG_SCF_FBW7_1	0.7078
p.T429I	DO9708	COAD	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	0.7078
p.E431K	TCGA-FW-A3R5	SKCM	TCGA	VPSTPEAS	DEG_SCF_FBW7_1	0.591
p.E431K	DO37406	SKCM	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	0.591
p.S428C	DO225367	BRCA	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	0.643
p.R416S	DO52455	COCA	ICGC	VPSTPEAS	DEG_SCF_FBW7_1	0.0556
p.V426I	ACH-001607	Gallbladder Cancer	CCLE	VPSTPEAS	DEG_SCF_FBW7_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NAM6	Zinc finger and SCAN domain-containing protein 4	DEG_SCF_FBW7_1	426:433	VPSTPEAS	FBXW7	0.5522	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons