DegronMD

Uniprot ID: P20794

Source protein: Serine/threonine-protein kinase MAK

Source gene: MAK

Class: LIG_APCC_ABBA_1

Location: 425:430

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5635

ASA_SCORE: 94.9833

COIL: 0.5068

CONS_SCORE: 0.3452

DSS_SCORE: 0.5703

HELIX: 0.478

FCONS_SCORE: 1.0424

RIG_SCORE: 0.6918

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R439W	TCGA-AA-A00N	COAD	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.R439W	TCGA-AX-A0J0	UCEC	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.R439W	TCGA-CA-6717	COAD	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.R439W	TCGA-EY-A1G8	UCEC	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.R439W	DO9876	COAD	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.R439W	DO8264	COAD	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.R439W	DO43578	UCEC	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.R439W	DO41133	UCEC	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.R439W	SIDM01611	Endometrial Carcinoma	GDSC	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.S436Y	TCGA-AG-A002	READ	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.1667
p.S436Y	TCGA-AP-A1E0	UCEC	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.1667
p.S436Y	DO43154	UCEC	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.1667
p.K434T	TCGA-AJ-A3EL	UCEC	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.3333
p.K434T	DO41542	UCEC	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.3333
p.G416R	TCGA-AP-A1E1	UCEC	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.G416R	DO233652	GACA	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.G416R	DO43226	UCEC	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.D435V	TCGA-CG-5721	STAD	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.1944
p.D435V	DO38192	STAD	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.1944
p.R432K	TCGA-FR-A726	SKCM	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.2778
p.R432K	TCGA-Z2-A8RT	SKCM	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.2778
p.R432K	DO48665	SKCM	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.2778
p.R432K	DO51301	SKCM	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.2778
p.P437S	TCGA-FR-A8YC	SKCM	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.1389
p.P437S	DO220851	MELA	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.1389
p.P437S	DO50301	SKCM	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.1389
p.D435Y	TCGA-IN-A6RL	STAD	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.1944
p.D435Y	DO51738	STAD	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.1944
p.P423A	TCGA-L3-A524	LUSC	TCGA	MGVFKE	LIG_APCC_ABBA_1	0.2778
p.P423A	DO45476	LUSC	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.2778
p.K421R	DO229013	COCA	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.3333
p.F428S	DO232032	LICA	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.7982
p.E430K	DO229052	LICA	ICGC	MGVFKE	LIG_APCC_ABBA_1	0.7022
p.R439Q	SIDM00761	Small Cell Lung Carcinoma	GDSC	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.R439Q	NCI-H196	lung	COSMIC	MGVFKE	LIG_APCC_ABBA_1	0.0833
p.R439H	NCI-H196	lung	COSMIC	MGVFKE	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MGVFKE

Degron related mutations and impact score

Drug responses associated with MAK mutations

All proteins holding degron of MGVFKE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20794	Serine/threonine-protein kinase MAK	LIG_APCC_ABBA_1	425:430	MGVFKE	APC,CDC20,FZR1	0.5635	More...