DegronMD - P20794(MAK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R439W	TCGA-AA-A00N	COAD	TCGA	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.0556
p.R439W	TCGA-AA-A00N	COAD	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.R439W	TCGA-AX-A0J0	UCEC	TCGA	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.0556
p.R439W	TCGA-AX-A0J0	UCEC	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.R439W	TCGA-CA-6717	COAD	TCGA	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.0556
p.R439W	TCGA-CA-6717	COAD	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.R439W	TCGA-EY-A1G8	UCEC	TCGA	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.0556
p.R439W	TCGA-EY-A1G8	UCEC	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.R439W	DO9876	COAD	ICGC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.0556
p.R439W	DO9876	COAD	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.R439W	DO8264	COAD	ICGC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.0556
p.R439W	DO8264	COAD	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.R439W	DO43578	UCEC	ICGC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.0556
p.R439W	DO43578	UCEC	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.R439W	DO41133	UCEC	ICGC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.0556
p.R439W	DO41133	UCEC	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.R439W	SIDM01611	Endometrial Carcinoma	GDSC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.0556
p.R439W	SIDM01611	Endometrial Carcinoma	GDSC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.S436Y	TCGA-AG-A002	READ	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.1667
p.S436Y	TCGA-AP-A1E0	UCEC	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.1667
p.S436Y	DO43154	UCEC	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.1667
p.K434T	TCGA-AJ-A3EL	UCEC	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation substituting flanking lysine	0.3333
p.K434T	DO41542	UCEC	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation substituting flanking lysine	0.3333
p.G416R	TCGA-AP-A1E1	UCEC	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.G416R	DO233652	GACA	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.G416R	DO43226	UCEC	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.D435V	TCGA-CG-5721	STAD	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.1944
p.D435V	DO38192	STAD	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.1944
p.E454K	TCGA-ER-A19F	SKCM	TCGA	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation altering degron motif	0.7022
p.E454K	DO37679	SKCM	ICGC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation altering degron motif	0.7022
p.R432K	TCGA-FR-A726	SKCM	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.2778
p.R432K	TCGA-Z2-A8RT	SKCM	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.2778
p.R432K	DO48665	SKCM	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.2778
p.R432K	DO51301	SKCM	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.2778
p.P437S	TCGA-FR-A8YC	SKCM	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.1389
p.P437S	DO220851	MELA	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.1389
p.P437S	DO50301	SKCM	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.1389
p.D435Y	TCGA-IN-A6RL	STAD	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.1944
p.D435Y	DO51738	STAD	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.1944
p.P423A	TCGA-L3-A524	LUSC	TCGA	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.2778
p.P423A	DO45476	LUSC	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.2778
p.S446L	TCGA-XF-A9ST	BLCA	TCGA	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.25
p.S446L	DO223599	BLCA	ICGC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.25
p.K421R	DO229013	COCA	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation substituting flanking lysine	0.3333
p.K456N	DO48207	ESCA	ICGC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.2778
p.F428S	DO232032	LICA	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation altering degron motif	0.7982
p.A460D	DO229019	LICA	ICGC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.1667
p.E430K	DO229052	LICA	ICGC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation altering degron motif	0.7022
p.P445T	DO229008	LICA	ICGC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.2222
p.S457R	DO230535	LUSC	ICGC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation blocking phosphorylation signal	0.6944
p.V444A	SIDM00555	Glioblastoma	GDSC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.1944
p.V444A	ACH-000631	Brain Cancer	CCLE	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.1944
p.V444A	KS-1	central nervous system	COSMIC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.1944
p.R439Q	SIDM00761	Small Cell Lung Carcinoma	GDSC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.0556
p.R439Q	SIDM00761	Small Cell Lung Carcinoma	GDSC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.R439Q	NCI-H196	lung	COSMIC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.0556
p.R439Q	NCI-H196	lung	COSMIC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833
p.G447S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.2778
p.G447S	ACH-000995	Leukemia	CCLE	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.2778
p.G447S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.2778
p.A460P	ACH-000887	Brain Cancer	CCLE	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.1667
p.R439H	NCI-H196	lung	COSMIC	NHSTGE	DEG_Kelch_Keap1_1	449:454	Mutation rewiring degron network	0.0556
p.R439H	NCI-H196	lung	COSMIC	MGVFKE	LIG_APCC_ABBA_1	425:430	Mutation rewiring degron network	0.0833

Kaplan plot for MAK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAK

UniProt ID: P20794

Entrez ID: 4117

Protein name: Serine/threonine-protein kinase MAK (EC 2.7.11.1) (Male germ cell-associated kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAK in