DegronMD

Uniprot ID: P20794

Source protein: Serine/threonine-protein kinase MAK

Source gene: MAK

Class: DEG_Kelch_Keap1_1

Location: 449:454

E3 ligase: KEAP1

DEGRON score: 0.6407

ASA_SCORE: 83.9167

COIL: 0.8935

CONS_SCORE: 0.3231

DSS_SCORE: 0.6684

HELIX: 0.0567

FCONS_SCORE: 1.0258

RIG_SCORE: 0.5445

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R439W	TCGA-AA-A00N	COAD	TCGA	NHSTGE	DEG_Kelch_Keap1_1	0.0556
p.R439W	TCGA-AX-A0J0	UCEC	TCGA	NHSTGE	DEG_Kelch_Keap1_1	0.0556
p.R439W	TCGA-CA-6717	COAD	TCGA	NHSTGE	DEG_Kelch_Keap1_1	0.0556
p.R439W	TCGA-EY-A1G8	UCEC	TCGA	NHSTGE	DEG_Kelch_Keap1_1	0.0556
p.R439W	DO9876	COAD	ICGC	NHSTGE	DEG_Kelch_Keap1_1	0.0556
p.R439W	DO8264	COAD	ICGC	NHSTGE	DEG_Kelch_Keap1_1	0.0556
p.R439W	DO43578	UCEC	ICGC	NHSTGE	DEG_Kelch_Keap1_1	0.0556
p.R439W	DO41133	UCEC	ICGC	NHSTGE	DEG_Kelch_Keap1_1	0.0556
p.R439W	SIDM01611	Endometrial Carcinoma	GDSC	NHSTGE	DEG_Kelch_Keap1_1	0.0556
p.E454K	TCGA-ER-A19F	SKCM	TCGA	NHSTGE	DEG_Kelch_Keap1_1	0.7022
p.E454K	DO37679	SKCM	ICGC	NHSTGE	DEG_Kelch_Keap1_1	0.7022
p.S446L	TCGA-XF-A9ST	BLCA	TCGA	NHSTGE	DEG_Kelch_Keap1_1	0.25
p.S446L	DO223599	BLCA	ICGC	NHSTGE	DEG_Kelch_Keap1_1	0.25
p.K456N	DO48207	ESCA	ICGC	NHSTGE	DEG_Kelch_Keap1_1	0.2778
p.A460D	DO229019	LICA	ICGC	NHSTGE	DEG_Kelch_Keap1_1	0.1667
p.P445T	DO229008	LICA	ICGC	NHSTGE	DEG_Kelch_Keap1_1	0.2222
p.S457R	DO230535	LUSC	ICGC	NHSTGE	DEG_Kelch_Keap1_1	0.6944
p.V444A	SIDM00555	Glioblastoma	GDSC	NHSTGE	DEG_Kelch_Keap1_1	0.1944
p.V444A	ACH-000631	Brain Cancer	CCLE	NHSTGE	DEG_Kelch_Keap1_1	0.1944
p.V444A	KS-1	central_nervous_system	COSMIC	NHSTGE	DEG_Kelch_Keap1_1	0.1944
p.R439Q	SIDM00761	Small Cell Lung Carcinoma	GDSC	NHSTGE	DEG_Kelch_Keap1_1	0.0556
p.R439Q	NCI-H196	lung	COSMIC	NHSTGE	DEG_Kelch_Keap1_1	0.0556
p.G447S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NHSTGE	DEG_Kelch_Keap1_1	0.2778
p.G447S	ACH-000995	Leukemia	CCLE	NHSTGE	DEG_Kelch_Keap1_1	0.2778
p.G447S	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	NHSTGE	DEG_Kelch_Keap1_1	0.2778
p.A460P	ACH-000887	Brain Cancer	CCLE	NHSTGE	DEG_Kelch_Keap1_1	0.1667
p.R439H	NCI-H196	lung	COSMIC	NHSTGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20794	Serine/threonine-protein kinase MAK	DEG_Kelch_Keap1_1	449:454	NHSTGE	KEAP1	0.6407	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NHSTGE

Degron related mutations and impact score

Drug responses associated with MAK mutations

All proteins holding degron of NHSTGE