DegronMD

Uniprot ID: Q86WK6

Source protein: Amphoterin-induced protein 1

Source gene: AMIGO1

Class: LIG_APCC_ABBA_1

Location: 1:6

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7485

ASA_SCORE: 108.8667

COIL: 0.9322

CONS_SCORE: 0.3397

DSS_SCORE: 0.5961

HELIX: 0.0593

FCONS_SCORE: 0.7896

RIG_SCORE: 0.7216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R5H	DO234410	ESAD	ICGC	MHPHRD	LIG_APCC_ABBA_1	0.7133
p.P7L	DO233156	GACA	ICGC	MHPHRD	LIG_APCC_ABBA_1	0.3056
p.P15L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	MHPHRD	LIG_APCC_ABBA_1	0.0833
p.P15L	ACH-000981	Leukemia	CCLE	MHPHRD	LIG_APCC_ABBA_1	0.0833
p.P15L	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	MHPHRD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WK6	Amphoterin-induced protein 1	LIG_APCC_ABBA_1	1:6	MHPHRD	APC,CDC20,FZR1	0.7485	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons