DegronMD

Uniprot ID: P13693

Source protein: Translationally-controlled tumor protein

Source gene: TPT1

Class: LIG_APCC_ABBA_1

Location: 1:6

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5353

ASA_SCORE: 56.2167

COIL: 0.2868

CONS_SCORE: 0.6458

DSS_SCORE: 0.4277

HELIX: 0.004

FCONS_SCORE: 0.9683

RIG_SCORE: 0.9206

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H10L	TCGA-ZP-A9D0	LIHC	TCGA	MIIYRD	LIG_APCC_ABBA_1	0.2222
p.L7F	DO230322	COCA	ICGC	MIIYRD	LIG_APCC_ABBA_1	0.3056
p.F2L	DO222884	COCA	ICGC	MIIYRD	LIG_APCC_ABBA_1	0.6981
p.R9L	DO14278	HNSC	ICGC	MIIYRD	LIG_APCC_ABBA_1	0.6944
p.R9L	DO39046	THCA	ICGC	MIIYRD	LIG_APCC_ABBA_1	0.6944
p.A12E	DO228948	LICA	ICGC	MIIYRD	LIG_APCC_ABBA_1	0.1667
p.R4G	ACH-000988	Endometrial/Uterine Cancer	CCLE	MIIYRD	LIG_APCC_ABBA_1	0.7568
p.R4G	MFE-319	endometrium	COSMIC	MIIYRD	LIG_APCC_ABBA_1	0.7568
p.V2I	ACH-000999	Colon/Colorectal Cancer	CCLE	MIIYRD	LIG_APCC_ABBA_1	0.7076
p.V2I	SNU-1040	large_intestine	COSMIC	MIIYRD	LIG_APCC_ABBA_1	0.7076
p.E6K	ACH-002097	Skin Cancer	CCLE	MIIYRD	LIG_APCC_ABBA_1	0.7022
p.E6K	CP66-MEL	skin	COSMIC	MIIYRD	LIG_APCC_ABBA_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13693	Translationally-controlled tumor protein	LIG_APCC_ABBA_1	1:6	MIIYRD	APC,CDC20,FZR1	0.5353	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons