DegronMD

Uniprot ID: Q9ULE3

Source protein: DENN domain-containing protein 2A

Source gene: DENND2A

Class: DEG_APCC_KENBOX_2

Location: 378:382

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9433

ASA_SCORE: 87.28

COIL: 0.8382

CONS_SCORE: 0.305

DSS_SCORE: 0.4051

HELIX: 0.0902

FCONS_SCORE: 1.0672

RIG_SCORE: 0.7272

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E387D	TCGA-17-Z061	LUAD	TCGA	MKENP	DEG_APCC_KENBOX_2	0.1944
p.E380V	TCGA-68-8251	LUSC	TCGA	MKENP	DEG_APCC_KENBOX_2	0.7693
p.E380V	DO26858	LUSC	ICGC	MKENP	DEG_APCC_KENBOX_2	0.7693
p.G390V	TCGA-BR-8370	STAD	TCGA	MKENP	DEG_APCC_KENBOX_2	0.1111
p.G390V	DO47771	STAD	ICGC	MKENP	DEG_APCC_KENBOX_2	0.1111
p.P376L	TCGA-BR-8487	STAD	TCGA	MKENP	DEG_APCC_KENBOX_2	0.2778
p.P376L	TCGA-EO-A22U	UCEC	TCGA	MKENP	DEG_APCC_KENBOX_2	0.2778
p.P376L	DO47867	STAD	ICGC	MKENP	DEG_APCC_KENBOX_2	0.2778
p.P376L	DO43755	UCEC	ICGC	MKENP	DEG_APCC_KENBOX_2	0.2778
p.I386V	TCGA-CG-4306	STAD	TCGA	MKENP	DEG_APCC_KENBOX_2	0.2222
p.I386V	DO38567	STAD	ICGC	MKENP	DEG_APCC_KENBOX_2	0.2222
p.E384D	TCGA-D1-A17M	UCEC	TCGA	MKENP	DEG_APCC_KENBOX_2	0.2778
p.E384D	DO43779	UCEC	ICGC	MKENP	DEG_APCC_KENBOX_2	0.2778
p.E380K	TCGA-D3-A2JN	SKCM	TCGA	MKENP	DEG_APCC_KENBOX_2	0.7022
p.E380K	DO47590	SKCM	ICGC	MKENP	DEG_APCC_KENBOX_2	0.7022
p.M378V	TCGA-EY-A1GK	UCEC	TCGA	MKENP	DEG_APCC_KENBOX_2	0.6097
p.M378V	DO42985	UCEC	ICGC	MKENP	DEG_APCC_KENBOX_2	0.6097
p.M378V	SIDM01664	Prostate Carcinoma	GDSC	MKENP	DEG_APCC_KENBOX_2	0.6097
p.M378V	ACH-000952	Prostate Cancer	CCLE	MKENP	DEG_APCC_KENBOX_2	0.6097
p.E384K	TCGA-MY-A913	CESC	TCGA	MKENP	DEG_APCC_KENBOX_2	0.2778
p.E384K	DO49980	CESC	ICGC	MKENP	DEG_APCC_KENBOX_2	0.2778
p.M378I	DO522	BLCA	ICGC	MKENP	DEG_APCC_KENBOX_2	0.6507
p.D385N	DO230336	COCA	ICGC	MKENP	DEG_APCC_KENBOX_2	0.25
p.N368D	DO48686	LIRI	ICGC	MKENP	DEG_APCC_KENBOX_2	0.0556
p.D375N	DO224566	LUSC	ICGC	MKENP	DEG_APCC_KENBOX_2	0.25
p.D375N	DO231007	LUSC	ICGC	MKENP	DEG_APCC_KENBOX_2	0.25
p.P376S	DO220875	MELA	ICGC	MKENP	DEG_APCC_KENBOX_2	0.2778
p.E380D	DO46779	PAEN	ICGC	MKENP	DEG_APCC_KENBOX_2	0.6758
p.V369I	SIDM01314	Colorectal Carcinoma	GDSC	MKENP	DEG_APCC_KENBOX_2	0.0833
p.R391H	SIDM00301	Pancreatic Carcinoma	GDSC	MKENP	DEG_APCC_KENBOX_2	0.0833
p.R391H	ACH-000265	Pancreatic Cancer	CCLE	MKENP	DEG_APCC_KENBOX_2	0.0833
p.R391H	KP-4	pancreas	COSMIC	MKENP	DEG_APCC_KENBOX_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MKENP

Degron related mutations and impact score

Drug responses associated with DENND2A mutations

All proteins holding degron of MKENP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULE3	DENN domain-containing protein 2A	DEG_APCC_KENBOX_2	378:382	MKENP	APC,CDC20,FZR1	0.9433	More...