DegronMD - Q9ULE3(DENND2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E387D	TCGA-17-Z061	LUAD	TCGA	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1944
p.G70R	TCGA-22-5477	LUSC	TCGA	VPTPAPS	DEG_SCF_FBW7_1	59:65	Mutation rewiring degron network	0.1944
p.G70R	TCGA-FS-A4F0	SKCM	TCGA	VPTPAPS	DEG_SCF_FBW7_1	59:65	Mutation rewiring degron network	0.1944
p.G70R	DO26894	LUSC	ICGC	VPTPAPS	DEG_SCF_FBW7_1	59:65	Mutation rewiring degron network	0.1944
p.G70R	DO37891	SKCM	ICGC	VPTPAPS	DEG_SCF_FBW7_1	59:65	Mutation rewiring degron network	0.1944
p.E380V	TCGA-68-8251	LUSC	TCGA	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation altering degron motif	0.7693
p.E380V	DO26858	LUSC	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation altering degron motif	0.7693
p.G390V	TCGA-BR-8370	STAD	TCGA	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1111
p.G390V	DO47771	STAD	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1111
p.P376L	TCGA-BR-8487	STAD	TCGA	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2778
p.P376L	TCGA-EO-A22U	UCEC	TCGA	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2778
p.P376L	DO47867	STAD	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2778
p.P376L	DO43755	UCEC	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2778
p.S65N	TCGA-C5-A7CO	CESC	TCGA	VPTPAPS	DEG_SCF_FBW7_1	59:65	Mutation altering degron motif	0.7069
p.S65N	DO49888	CESC	ICGC	VPTPAPS	DEG_SCF_FBW7_1	59:65	Mutation altering degron motif	0.7069
p.I386V	TCGA-CG-4306	STAD	TCGA	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2222
p.I386V	DO38567	STAD	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2222
p.E384D	TCGA-D1-A17M	UCEC	TCGA	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2778
p.E384D	DO43779	UCEC	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2778
p.E380K	TCGA-D3-A2JN	SKCM	TCGA	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation altering degron motif	0.7022
p.E380K	DO47590	SKCM	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation altering degron motif	0.7022
p.M378V	TCGA-EY-A1GK	UCEC	TCGA	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation altering degron motif	0.6097
p.M378V	DO42985	UCEC	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation altering degron motif	0.6097
p.M378V	SIDM01664	Prostate Carcinoma	GDSC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation altering degron motif	0.6097
p.M378V	ACH-000952	Prostate Cancer	CCLE	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation altering degron motif	0.6097
p.G70E	TCGA-FS-A4F0	SKCM	TCGA	VPTPAPS	DEG_SCF_FBW7_1	59:65	Mutation rewiring degron network	0.1944
p.G70E	DO37891	SKCM	ICGC	VPTPAPS	DEG_SCF_FBW7_1	59:65	Mutation rewiring degron network	0.1944
p.E384K	TCGA-MY-A913	CESC	TCGA	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2778
p.E384K	DO49980	CESC	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2778
p.P62S	TCGA-Z2-A8RT	SKCM	TCGA	VPTPAPS	DEG_SCF_FBW7_1	59:65	Mutation altering degron motif	0.6752
p.P62S	DO51301	SKCM	ICGC	VPTPAPS	DEG_SCF_FBW7_1	59:65	Mutation altering degron motif	0.6752
p.M378I	DO522	BLCA	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation altering degron motif	0.6507
p.D385N	DO230336	COCA	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.25
p.E72K	DO234289	ESAD	ICGC	VPTPAPS	DEG_SCF_FBW7_1	59:65	Mutation rewiring degron network	0.1389
p.N368D	DO48686	LIRI	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.0556
p.D375N	DO224566	LUSC	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.25
p.D375N	DO231007	LUSC	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.25
p.P376S	DO220875	MELA	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2778
p.E380D	DO46779	PAEN	ICGC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation altering degron motif	0.6758
p.V369I	SIDM01314	Colorectal Carcinoma	GDSC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.0833
p.R391H	SIDM00301	Pancreatic Carcinoma	GDSC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.0833
p.R391H	ACH-000265	Pancreatic Cancer	CCLE	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.0833
p.R391H	KP-4	pancreas	COSMIC	MKENP	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.0833
p.P60S	ACH-000495	Kidney Cancer	CCLE	VPTPAPS	DEG_SCF_FBW7_1	59:65	Mutation altering degron motif	0.5641

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DENND2A

UniProt ID: Q9ULE3

Entrez ID: 27147

Protein name: DENN domain-containing protein 2A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DENND2A in