DegronMD

Uniprot ID: Q9ULE3

Source protein: DENN domain-containing protein 2A

Source gene: DENND2A

Class: DEG_SCF_FBW7_1

Location: 59:65

E3 ligase: FBXW7

DEGRON score: 0.995

ASA_SCORE: 75.7429

COIL: 0.944

CONS_SCORE: 0.2772

DSS_SCORE: 0.6635

HELIX: 0.0231

FCONS_SCORE: 0.9783

RIG_SCORE: 0.6349

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G70R	TCGA-22-5477	LUSC	TCGA	VPTPAPS	DEG_SCF_FBW7_1	0.1944
p.G70R	TCGA-FS-A4F0	SKCM	TCGA	VPTPAPS	DEG_SCF_FBW7_1	0.1944
p.G70R	DO26894	LUSC	ICGC	VPTPAPS	DEG_SCF_FBW7_1	0.1944
p.G70R	DO37891	SKCM	ICGC	VPTPAPS	DEG_SCF_FBW7_1	0.1944
p.S65N	TCGA-C5-A7CO	CESC	TCGA	VPTPAPS	DEG_SCF_FBW7_1	0.7069
p.S65N	DO49888	CESC	ICGC	VPTPAPS	DEG_SCF_FBW7_1	0.7069
p.G70E	TCGA-FS-A4F0	SKCM	TCGA	VPTPAPS	DEG_SCF_FBW7_1	0.1944
p.G70E	DO37891	SKCM	ICGC	VPTPAPS	DEG_SCF_FBW7_1	0.1944
p.P62S	TCGA-Z2-A8RT	SKCM	TCGA	VPTPAPS	DEG_SCF_FBW7_1	0.6752
p.P62S	DO51301	SKCM	ICGC	VPTPAPS	DEG_SCF_FBW7_1	0.6752
p.E72K	DO234289	ESAD	ICGC	VPTPAPS	DEG_SCF_FBW7_1	0.1389
p.P60S	ACH-000495	Kidney Cancer	CCLE	VPTPAPS	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULE3	DENN domain-containing protein 2A	DEG_SCF_FBW7_1	59:65	VPTPAPS	FBXW7	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons