DegronMD

Uniprot ID: Q5T764

Source protein: Interferon-induced protein with tetratricopeptide repeats 1B

Source gene: IFIT1B

Class: LIG_APCC_ABBA_1

Location: 369:374

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8344

ASA_SCORE: 85.3833

COIL: 0.8288

CONS_SCORE: 0.4896

DSS_SCORE: 0.2855

HELIX: 0.1565

FCONS_SCORE: 0.8814

RIG_SCORE: 0.835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E379D	TCGA-AP-A1DV	UCEC	TCGA	MKIFED	LIG_APCC_ABBA_1	0.1944
p.E379D	DO43186	UCEC	ICGC	MKIFED	LIG_APCC_ABBA_1	0.1944
p.M369I	TCGA-BS-A0UF	UCEC	TCGA	MKIFED	LIG_APCC_ABBA_1	0.6507
p.M369I	TCGA-CA-6717	COAD	TCGA	MKIFED	LIG_APCC_ABBA_1	0.6507
p.M369I	DO8264	COAD	ICGC	MKIFED	LIG_APCC_ABBA_1	0.6507
p.M369I	DO41488	UCEC	ICGC	MKIFED	LIG_APCC_ABBA_1	0.6507
p.L367V	DO233288	GACA	ICGC	MKIFED	LIG_APCC_ABBA_1	0.2778
p.E361K	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	MKIFED	LIG_APCC_ABBA_1	0.1111
p.E361K	ACH-000823	Esophageal Cancer	CCLE	MKIFED	LIG_APCC_ABBA_1	0.1111
p.E361K	KYSE-140	oesophagus	COSMIC	MKIFED	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T764	Interferon-induced protein with tetratricopeptide repeats 1B	LIG_APCC_ABBA_1	369:374	MKIFED	APC,CDC20,FZR1	0.8344	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons