DegronMD - Q5T764(IFIT1B)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E379D	TCGA-AP-A1DV	UCEC	TCGA	MKIFED	LIG_APCC_ABBA_1	369:374	Mutation rewiring degron network	0.1944
p.E379D	TCGA-AP-A1DV	UCEC	TCGA	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.1944
p.E379D	DO43186	UCEC	ICGC	MKIFED	LIG_APCC_ABBA_1	369:374	Mutation rewiring degron network	0.1944
p.E379D	DO43186	UCEC	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.1944
p.R368H	TCGA-B5-A3FA	UCEC	TCGA	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation altering degron motif	0.8244
p.R368H	TCGA-EI-6882	READ	TCGA	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation altering degron motif	0.8244
p.R368H	DO36531	READ	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation altering degron motif	0.8244
p.R368H	DO52402	UCEC	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation altering degron motif	0.8244
p.R368H	SIDM00942	Oral Cavity Carcinoma	GDSC	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation altering degron motif	0.8244
p.M369I	TCGA-BS-A0UF	UCEC	TCGA	MKIFED	LIG_APCC_ABBA_1	369:374	Mutation altering degron motif	0.6507
p.M369I	TCGA-BS-A0UF	UCEC	TCGA	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation altering degron motif	0.6507
p.M369I	TCGA-CA-6717	COAD	TCGA	MKIFED	LIG_APCC_ABBA_1	369:374	Mutation altering degron motif	0.6507
p.M369I	TCGA-CA-6717	COAD	TCGA	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation altering degron motif	0.6507
p.M369I	DO8264	COAD	ICGC	MKIFED	LIG_APCC_ABBA_1	369:374	Mutation altering degron motif	0.6507
p.M369I	DO8264	COAD	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation altering degron motif	0.6507
p.M369I	DO41488	UCEC	ICGC	MKIFED	LIG_APCC_ABBA_1	369:374	Mutation altering degron motif	0.6507
p.M369I	DO41488	UCEC	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation altering degron motif	0.6507
p.K358Q	TCGA-C5-A8YQ	CESC	TCGA	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation substituting flanking lysine	0.1667
p.K358Q	DO49906	CESC	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation substituting flanking lysine	0.1667
p.L367V	DO233288	GACA	ICGC	MKIFED	LIG_APCC_ABBA_1	369:374	Mutation rewiring degron network	0.2778
p.L367V	DO233288	GACA	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.3056
p.E361K	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	MKIFED	LIG_APCC_ABBA_1	369:374	Mutation rewiring degron network	0.1111
p.E361K	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.1389
p.E361K	ACH-000823	Esophageal Cancer	CCLE	MKIFED	LIG_APCC_ABBA_1	369:374	Mutation rewiring degron network	0.1111
p.E361K	ACH-000823	Esophageal Cancer	CCLE	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.1389
p.E361K	KYSE-140	oesophagus	COSMIC	MKIFED	LIG_APCC_ABBA_1	369:374	Mutation rewiring degron network	0.1111
p.E361K	KYSE-140	oesophagus	COSMIC	RMKIFED	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IFIT1B

UniProt ID: Q5T764

Entrez ID: 439996

Protein name: Interferon-induced protein with tetratricopeptide repeats 1B (Interferon-induced protein with tetratricopeptide repeats 1-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IFIT1B in