DegronMD

Uniprot ID: Q5T764

Source protein: Interferon-induced protein with tetratricopeptide repeats 1B

Source gene: IFIT1B

Class: LIG_APCC_ABBAyCdc20_2

Location: 368:374

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6539

ASA_SCORE: 95.2571

COIL: 0.8251

CONS_SCORE: 0.4972

DSS_SCORE: 0.2927

HELIX: 0.1593

FCONS_SCORE: 0.8931

RIG_SCORE: 0.8307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E379D	TCGA-AP-A1DV	UCEC	TCGA	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.E379D	DO43186	UCEC	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.R368H	TCGA-B5-A3FA	UCEC	TCGA	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.8244
p.R368H	TCGA-EI-6882	READ	TCGA	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.8244
p.R368H	DO36531	READ	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.8244
p.R368H	DO52402	UCEC	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.8244
p.R368H	SIDM00942	Oral Cavity Carcinoma	GDSC	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.8244
p.M369I	TCGA-BS-A0UF	UCEC	TCGA	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.6507
p.M369I	TCGA-CA-6717	COAD	TCGA	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.6507
p.M369I	DO8264	COAD	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.6507
p.M369I	DO41488	UCEC	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.6507
p.K358Q	TCGA-C5-A8YQ	CESC	TCGA	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.1667
p.K358Q	DO49906	CESC	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.1667
p.L367V	DO233288	GACA	ICGC	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.3056
p.E361K	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.E361K	ACH-000823	Esophageal Cancer	CCLE	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.E361K	KYSE-140	oesophagus	COSMIC	RMKIFED	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T764	Interferon-induced protein with tetratricopeptide repeats 1B	LIG_APCC_ABBAyCdc20_2	368:374	RMKIFED	APC,CDC20,FZR1	0.6539	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons