DegronMD

Uniprot ID: Q9UPU7

Source protein: TBC1 domain family member 2B

Source gene: TBC1D2B

Class: DEG_SCF_FBW7_1

Location: 549:555

E3 ligase: FBXW7

DEGRON score: 0.9735

ASA_SCORE: 59.5714

COIL: 0.7679

CONS_SCORE: 0.2375

DSS_SCORE: 0.3139

HELIX: 0.1603

FCONS_SCORE: 0.824

RIG_SCORE: 0.7854

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V553L	TCGA-AX-A2HJ	UCEC	TCGA	MKTPVCS	DEG_SCF_FBW7_1	0.5654
p.V553L	DO42105	UCEC	ICGC	MKTPVCS	DEG_SCF_FBW7_1	0.5654
p.D557N	TCGA-BF-A5EO	SKCM	TCGA	MKTPVCS	DEG_SCF_FBW7_1	0.2778
p.D557N	DO219450	SKCM	ICGC	MKTPVCS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPU7	TBC1 domain family member 2B	DEG_SCF_FBW7_1	549:555	MKTPVCS	FBXW7	0.9735	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons