DegronMD

Uniprot ID: Q8TB05

Source protein: UBA-like domain-containing protein 1

Source gene: UBALD1

Class: DEG_SCF_FBW7_1

Location: 61:68

E3 ligase: FBXW7

DEGRON score: 0.9787

ASA_SCORE: 71.45

COIL: 0.841

CONS_SCORE: 0.8011

DSS_SCORE: 0.4788

HELIX: 0.0706

FCONS_SCORE: 1.1028

RIG_SCORE: 0.6715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P74L	DO233210	GACA	ICGC	MMCTPANT	DEG_SCF_FBW7_1	0.1667
p.R71H	DO233766	GACA	ICGC	MMCTPANT	DEG_SCF_FBW7_1	0.25
p.P74Q	DO228986	LICA	ICGC	MMCTPANT	DEG_SCF_FBW7_1	0.1667
p.P60T	DO229031	LICA	ICGC	MMCTPANT	DEG_SCF_FBW7_1	0.3056
p.T54K	DO229038	LICA	ICGC	MMCTPANT	DEG_SCF_FBW7_1	0.1389
p.T64P	DO229204	THCA	ICGC	MMCTPANT	DEG_SCF_FBW7_1	0.7031
p.T64P	DO229088	THCA	ICGC	MMCTPANT	DEG_SCF_FBW7_1	0.7031
p.T64P	DO229092	THCA	ICGC	MMCTPANT	DEG_SCF_FBW7_1	0.7031
p.S55T	SIDM00305	Ovarian Carcinoma	GDSC	MMCTPANT	DEG_SCF_FBW7_1	0.1667
p.S55T	ACH-000132	Ovarian Cancer	CCLE	MMCTPANT	DEG_SCF_FBW7_1	0.1667
p.P73S	ACH-000884	Skin Cancer	CCLE	MMCTPANT	DEG_SCF_FBW7_1	0.1944
p.V66G	LB996-RCC	kidney	COSMIC	MMCTPANT	DEG_SCF_FBW7_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TB05	UBA-like domain-containing protein 1	DEG_SCF_FBW7_1	61:68	MMCTPANT	FBXW7	0.9787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons